DAR - Bologna Biocomputing Group

Search summary (EC number: 1.14.11.68)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	3
Number of reactions:	31

Search results (EC number: 1.14.11.68)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010465	KDM6A	O15550	1.14.11.68	R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Developmental Biology	R-HSA-4754187 ( R-HSA-3214842 ) R-HSA-4754187 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-5661121 ( R-HSA-3214842 ) R-HSA-5661121 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-6810139 ( R-HSA-5617472 ) R-HSA-6810139 Reaction Name: HOXA2 chromatin is activated See in Reactome R-HSA-6810158 ( R-HSA-5617472 ) R-HSA-6810158 Reaction Name: HOXB3 chromatin is activated See in Reactome R-HSA-6810159 ( R-HSA-5617472 ) R-HSA-6810159 Reaction Name: HOXB2 chromatin is activated See in Reactome R-HSA-6810161 ( R-HSA-5617472 ) R-HSA-6810161 Reaction Name: HOXA3 chromatin is activated See in Reactome
MONDO:0032790	KDM6B	O15054	1.14.11.68	R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Cellular responses to stimuli	R-HSA-3222546 ( R-HSA-2559580 ) R-HSA-3222546 Reaction Name: AP-1 complex stimulates KDM6B transcription See in Reactome R-HSA-3222593 ( R-HSA-2559580 ) R-HSA-3222593 Reaction Name: KDM6B demethylates H3K27me3 on p16INK4A promoter See in Reactome R-HSA-3223200 ( R-HSA-2559580 ) R-HSA-3223200 Reaction Name: Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription See in Reactome R-HSA-4754187 ( R-HSA-3214842 ) R-HSA-4754187 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 See in Reactome R-HSA-5661121 ( R-HSA-3214842 ) R-HSA-5661121 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 See in Reactome R-HSA-8979071 ( R-HSA-2559580 ) R-HSA-8979071 Reaction Name: KDM6B binds iron See in Reactome