DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	P4HTM	Q9NXG6	1.14.11.29
MONDO:0012353	EGLN1	Q9GZT9	1.14.11.29	R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome	Cellular responses to stimuli	R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1234163 ( R-HSA-1234176 ) R-HSA-1234163 Reaction Name: Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha See in Reactome R-HSA-1234173 ( R-HSA-1234176 ) R-HSA-1234173 Reaction Name: Cytosolic PHD2,3 hydroxylates proline residues on HIF3A See in Reactome R-HSA-1234177 ( R-HSA-1234176 ) R-HSA-1234177 Reaction Name: Cytosolic PHD2,3 hydroxylates proline residues on HIF1A See in Reactome R-HSA-1234179 ( R-HSA-1234176 ) R-HSA-1234179 Reaction Name: Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) See in Reactome R-HSA-1234183 ( R-HSA-1234176 ) R-HSA-1234183 Reaction Name: Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha See in Reactome
MONDO:0032780	P4HTM	Q9NXG6	1.14.11.29