DAR - Bologna Biocomputing Group

Search summary (EC number: 1.1.1.35)

Number of enzymes:	3
Number of disease:	6
Number of reactomes:	11
Number of reactions:	16

Search results (EC number: 1.1.1.35)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009278	HADH	Q16836	1.1.1.35	R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome R-HSA-77352 R-HSA-77352 Reactome Name: Beta oxidation of butanoyl-CoA to acetyl-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome	Metabolism	R-HSA-77254 ( R-HSA-77310 ) R-HSA-77254 Reaction Name: (S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H See in Reactome R-HSA-77312 ( R-HSA-77352 ) R-HSA-77312 Reaction Name: (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H See in Reactome R-HSA-77323 ( R-HSA-77350 ) R-HSA-77323 Reaction Name: (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H See in Reactome R-HSA-77331 ( R-HSA-77348 ) R-HSA-77331 Reaction Name: (S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H See in Reactome R-HSA-77342 ( R-HSA-77346 ) R-HSA-77342 Reaction Name: (S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H See in Reactome
MONDO:0009855	EHHADH	Q08426	5.3.3.8 1.1.1.35 4.2.1.17	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Metabolism Protein localization	R-HSA-6809263 ( R-HSA-390247 ) R-HSA-6809263 Reaction Name: EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-6809264 ( R-HSA-390247 ) R-HSA-6809264 Reaction Name: EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0012382	HADH	Q16836	1.1.1.35	R-HSA-77346 R-HSA-77346 Reactome Name: Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA See in Reactome R-HSA-77310 R-HSA-77310 Reactome Name: Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA See in Reactome R-HSA-77348 R-HSA-77348 Reactome Name: Beta oxidation of octanoyl-CoA to hexanoyl-CoA See in Reactome R-HSA-77352 R-HSA-77352 Reactome Name: Beta oxidation of butanoyl-CoA to acetyl-CoA See in Reactome R-HSA-77350 R-HSA-77350 Reactome Name: Beta oxidation of hexanoyl-CoA to butanoyl-CoA See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-77286 R-HSA-77286 Reactome Name: mitochondrial fatty acid beta-oxidation of saturated fatty acids See in Reactome	Metabolism	R-HSA-77254 ( R-HSA-77310 ) R-HSA-77254 Reaction Name: (S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H See in Reactome R-HSA-77312 ( R-HSA-77352 ) R-HSA-77312 Reaction Name: (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H See in Reactome R-HSA-77323 ( R-HSA-77350 ) R-HSA-77323 Reaction Name: (S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H See in Reactome R-HSA-77331 ( R-HSA-77348 ) R-HSA-77331 Reaction Name: (S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H See in Reactome R-HSA-77342 ( R-HSA-77346 ) R-HSA-77342 Reaction Name: (S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H See in Reactome
MONDO:0014275	EHHADH	Q08426	5.3.3.8 1.1.1.35 4.2.1.17	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Metabolism Protein localization	R-HSA-6809263 ( R-HSA-390247 ) R-HSA-6809263 Reaction Name: EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-6809264 ( R-HSA-390247 ) R-HSA-6809264 Reaction Name: EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0018322	HSD17B10	Q99714	1.1.1.62 1.1.1.35 1.1.1.239 1.1.1.178 1.1.1.159 1.1.1.53	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome	Metabolism of RNA Metabolism	R-HSA-508369 ( R-HSA-70895 ) R-HSA-508369 Reaction Name: alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ See in Reactome R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome R-HSA-70837 ( R-HSA-70895 ) R-HSA-70837 Reaction Name: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ See in Reactome
MONDO:0018323	HSD17B10	Q99714	1.1.1.62 1.1.1.35 1.1.1.239 1.1.1.178 1.1.1.159 1.1.1.53	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome	Metabolism of RNA Metabolism	R-HSA-508369 ( R-HSA-70895 ) R-HSA-508369 Reaction Name: alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ See in Reactome R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome R-HSA-70837 ( R-HSA-70895 ) R-HSA-70837 Reaction Name: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ See in Reactome