DAR - Bologna Biocomputing Group

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0012994	SPR	P35270	1.1.1.153	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-1475414 ( R-HSA-1474151 ) R-HSA-1475414 Reaction Name: PTHP is reduced to BH4 by sepiapterin reductase (SPR) See in Reactome R-HSA-1497853 ( R-HSA-1474151 ) R-HSA-1497853 Reaction Name: Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II See in Reactome R-HSA-1497869 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497869 Reaction Name: Salvage - Sepiapterin is reduced to BH2 See in Reactome

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