DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0030074)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	8
Number of reactions:	11

Search results (Disease ID: MONDO:0030074)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0030074	PLCB3	Q01970	3.1.4.11	R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-399997 R-HSA-399997 Reactome Name: Acetylcholine regulates insulin secretion See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-434316 R-HSA-434316 Reactome Name: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion See in Reactome R-HSA-500657 R-HSA-500657 Reactome Name: Presynaptic function of Kainate receptors See in Reactome R-HSA-418217 R-HSA-418217 Reactome Name: G beta:gamma signalling through PLC beta See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-451326 R-HSA-451326 Reactome Name: Activation of kainate receptors upon glutamate binding See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Neuronal System Signal Transduction	R-HSA-111870 ( R-HSA-112043 ) R-HSA-111870 Reaction Name: Activation of PLC beta-1/4 See in Reactome R-HSA-111879 ( R-HSA-112043 ) R-HSA-111879 Reaction Name: PIP2 hydrolysis See in Reactome R-HSA-112037 ( R-HSA-112043 ) R-HSA-112037 Reaction Name: Inactivation of PLC beta See in Reactome R-HSA-114688 ( R-HSA-416476 ) R-HSA-114688 Reaction Name: PLC-beta hydrolyses PIP2 to DAG and IP3 See in Reactome R-HSA-1855177 ( R-HSA-1855204 ) R-HSA-1855177 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane See in Reactome R-HSA-398040 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398040 Reaction Name: Gbeta:gamma activation of PLC beta See in Reactome R-HSA-398188 ( R-HSA-416476 ) R-HSA-398188 Reaction Name: PLC beta is activated by G alpha (q) See in Reactome R-HSA-398193 ( R-HSA-4086398; R-HSA-418217 ) R-HSA-398193 Reaction Name: PLC beta-mediated PIP2 hydrolysis See in Reactome R-HSA-399998 ( R-HSA-399997; R-HSA-434316 ) R-HSA-399998 Reaction Name: Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-400023 ( R-HSA-399997; R-HSA-434316 ) R-HSA-400023 Reaction Name: Gq alpha activates Phospholipase C beta See in Reactome R-HSA-500717 ( R-HSA-500657 ) R-HSA-500717 Reaction Name: Activation of GRIK3 homomer See in Reactome