DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0020437	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome