DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0018874)

Number of enzymes:	6
Number of disease:	1
Number of reactomes:	80
Number of reactions:	261

Search results (Disease ID: MONDO:0018874)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018874	TERT	O14746	2.7.7.49	R-HSA-171319 R-HSA-171319 Reactome Name: Telomere Extension By Telomerase See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Signal Transduction	R-HSA-163090 ( R-HSA-171319 ) R-HSA-163090 Reaction Name: Elongation Of The Telomeric Chromosome End See in Reactome R-HSA-163096 ( R-HSA-171319 ) R-HSA-163096 Reaction Name: Recruitment of Telomerase RNP to the Telomeric Chromosome End See in Reactome R-HSA-163099 ( R-HSA-171319 ) R-HSA-163099 Reaction Name: Alignment Of The RNA Template On The Telomeric Chromosome End See in Reactome R-HSA-163120 ( R-HSA-171319 ) R-HSA-163120 Reaction Name: Disassociation of Telomerase RNP and the Chromosome End See in Reactome R-HSA-164616 ( R-HSA-171319 ) R-HSA-164616 Reaction Name: Biogenesis and assembly of the telomerase RNP See in Reactome R-HSA-164617 ( R-HSA-171319 ) R-HSA-164617 Reaction Name: Elongation of Extended Telomeric Chromosome End See in Reactome R-HSA-164620 ( R-HSA-171319 ) R-HSA-164620 Reaction Name: Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End See in Reactome R-HSA-3322422 ( R-HSA-201722 ) R-HSA-3322422 Reaction Name: Beta-catenin recruits SMARCA4 See in Reactome
MONDO:0018874	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0018874	DNMT3A	Q9Y6K1	2.1.1.37 2.1.1.-	R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-4655427 R-HSA-4655427 Reactome Name: SUMOylation of DNA methylation proteins See in Reactome R-HSA-212300 R-HSA-212300 Reactome Name: PRC2 methylates histones and DNA See in Reactome R-HSA-5334118 R-HSA-5334118 Reactome Name: DNA methylation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Gene expression (Transcription) Metabolism of proteins Chromatin organization	R-HSA-212222 ( R-HSA-212300 ) R-HSA-212222 Reaction Name: PRC2 recruits DNA methyltransferases See in Reactome R-HSA-212269 ( R-HSA-212300 ) R-HSA-212269 Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 See in Reactome R-HSA-4655440 ( R-HSA-4655427 ) R-HSA-4655440 Reaction Name: CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 See in Reactome R-HSA-5212679 ( R-HSA-3214858 ) R-HSA-5212679 Reaction Name: DNMT3A binds Me2sR4-HIST1H4 See in Reactome R-HSA-5334152 ( R-HSA-5334118 ) R-HSA-5334152 Reaction Name: DNMT3A:DNMT3L methylates cytosine in DNA See in Reactome R-HSA-5334179 ( R-HSA-5334118 ) R-HSA-5334179 Reaction Name: DNMT3A:DNMT3L binds chromatin See in Reactome
MONDO:0018874	SETD2	Q9BYW2	2.1.1.359 2.1.1.-	R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-5638141 ( R-HSA-3214841 ) R-HSA-5638141 Reaction Name: SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) See in Reactome
MONDO:0018874	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0018874	PDGFRB	P09619	2.7.10.1	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-1524182 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524182 Reaction Name: Activated PLC gamma dissociates from the PDGF receptor See in Reactome R-HSA-1524186 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524186 Reaction Name: Phosphorylation of PLCgamma by PDGFR See in Reactome R-HSA-186765 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186765 Reaction Name: PLC-gamma binds to the active receptor See in Reactome R-HSA-186773 ( R-HSA-186797 ) R-HSA-186773 Reaction Name: PDGF dimer binds two receptors simultaneously See in Reactome R-HSA-186778 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-186780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186786 ( R-HSA-186797 ) R-HSA-186786 Reaction Name: Autophosphorylation of PDGF beta receptors See in Reactome R-HSA-186798 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186798 Reaction Name: GAP binds to PDGF-beta receptors only See in Reactome R-HSA-186800 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-186819 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-186826 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186826 Reaction Name: GRB2:SOS1 complex binds to the active receptor See in Reactome R-HSA-186834 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-380780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-380782 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380782 Reaction Name: STAT binds to the active receptor See in Reactome R-HSA-382052 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382052 Reaction Name: p130Cas and C3G bind PDGFR bound Crk See in Reactome R-HSA-382055 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382055 Reaction Name: Grb7 binds to the active PDGF receptor See in Reactome R-HSA-382056 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382056 Reaction Name: Crk binds to the active PDGF receptor See in Reactome R-HSA-382058 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382058 Reaction Name: Nck binds to the active PDGF receptor See in Reactome R-HSA-389086 ( R-HSA-186797 ) R-HSA-389086 Reaction Name: Autophosphorylation of PDGF alpha/beta receptors See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864036 ( R-HSA-186797 ) R-HSA-8864036 Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021 See in Reactome R-HSA-9674095 ( R-HSA-186797 ) R-HSA-9674095 Reaction Name: PDGFRs bind type II TKI See in Reactome