DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0018298)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	7
Number of reactions:	45

Search results (Disease ID: MONDO:0018298)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018298	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0018298	MMP14	P50281	3.4.24.80	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-1592349 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592349 Reaction Name: MMP14 (MT1-MMP) binds TIMP2 See in Reactome R-HSA-1602466 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602466 Reaction Name: Activation of MT-MMPs by FURIN See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1605825 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1605825 Reaction Name: MT-MMPs are sorted to the plasma membrane See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-2533965 ( R-HSA-1474228 ) R-HSA-2533965 Reaction Name: NID1 degradation by MMP14, MMP15 See in Reactome R-HSA-2534240 ( R-HSA-1474228 ) R-HSA-2534240 Reaction Name: HSPG2 (perlecan) degradation by MMP14, MMP15 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome