DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0016865)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	7
Number of reactions:	53

Search results (Disease ID: MONDO:0016865)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0016865	EHMT1	Q9H9B1	2.1.1.- 2.1.1.367	R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-8853884 R-HSA-8853884 Reactome Name: Transcriptional Regulation by VENTX See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Chromatin organization	R-HSA-3788724 ( R-HSA-2559582 ) R-HSA-3788724 Reaction Name: Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 See in Reactome R-HSA-3788725 ( R-HSA-2559582 ) R-HSA-3788725 Reaction Name: Cdh1:APC/C complex binds EHMT1:EHMT2 See in Reactome R-HSA-3788745 ( R-HSA-2559582 ) R-HSA-3788745 Reaction Name: EHMT1:EHMT2 methylates IL8 promoter See in Reactome R-HSA-3788748 ( R-HSA-2559582 ) R-HSA-3788748 Reaction Name: EHMT1:EHMT2 methylates IL6 promoter See in Reactome R-HSA-3790130 ( R-HSA-2559582; R-HSA-8853884 ) R-HSA-3790130 Reaction Name: Regulation of IL6 transcription See in Reactome R-HSA-3790137 ( R-HSA-2559582 ) R-HSA-3790137 Reaction Name: Stimulation of IL8 transcription in senescent cells See in Reactome R-HSA-5634729 ( R-HSA-3214841 ) R-HSA-5634729 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-5634750 ( R-HSA-3214841 ) R-HSA-5634750 Reaction Name: EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) See in Reactome R-HSA-6805755 ( R-HSA-6804760 ) R-HSA-6805755 Reaction Name: EHMT1:EHMT2 dimethylates TP53 See in Reactome R-HSA-8953418 ( R-HSA-8953750 ) R-HSA-8953418 Reaction Name: EHMT1:EHMT2 complex binds E2F6.com-1 core See in Reactome R-HSA-8953452 ( R-HSA-8953750 ) R-HSA-8953452 Reaction Name: E2F6.com-1 complex binds the E2F1 gene promoter See in Reactome R-HSA-8953556 ( R-HSA-8953750 ) R-HSA-8953556 Reaction Name: E2F1 gene transcription is inhibited by E2F6 See in Reactome R-HSA-9007283 ( R-HSA-8953750 ) R-HSA-9007283 Reaction Name: CBX3 and PRC1.6 associate with E2F6.com-1 See in Reactome
MONDO:0016865	KMT2C	Q8NEZ4	2.1.1.364	R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Chromatin organization Developmental Biology	R-HSA-5159245 ( R-HSA-3214841 ) R-HSA-5159245 Reaction Name: SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-5244692 ( R-HSA-3214841 ) R-HSA-5244692 Reaction Name: Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-5637686 ( R-HSA-3214841 ) R-HSA-5637686 Reaction Name: WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-6810139 ( R-HSA-5617472 ) R-HSA-6810139 Reaction Name: HOXA2 chromatin is activated See in Reactome R-HSA-6810158 ( R-HSA-5617472 ) R-HSA-6810158 Reaction Name: HOXB3 chromatin is activated See in Reactome R-HSA-6810159 ( R-HSA-5617472 ) R-HSA-6810159 Reaction Name: HOXB2 chromatin is activated See in Reactome R-HSA-6810161 ( R-HSA-5617472 ) R-HSA-6810161 Reaction Name: HOXA3 chromatin is activated See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome