DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0015356)

Number of enzymes:	8
Number of disease:	1
Number of reactomes:	58
Number of reactions:	228

Search results (Disease ID: MONDO:0015356)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0015356	MRE11	P49959	3.1.-.-	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Immune System Cell Cycle Gene expression (Transcription) Reproduction Cellular responses to stimuli DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3204303 ( R-HSA-1834949 ) R-HSA-3204303 Reaction Name: MRE11 binds cytosolic DNA See in Reactome R-HSA-3785768 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-3785768 Reaction Name: MRN complex binds DNA double strand breaks See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682020 ( R-HSA-2559586 ) R-HSA-5682020 Reaction Name: MRN complex binds shortened telomeres See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75172 ( R-HSA-5693548 ) R-HSA-75172 Reaction Name: Formation of RAD50:MRE11 complex See in Reactome R-HSA-75174 ( R-HSA-5693548 ) R-HSA-75174 Reaction Name: Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0015356	SDHA	P31040	1.3.5.1	R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163213 ( R-HSA-611105 ) R-HSA-163213 Reaction Name: Transfer of electrons through the succinate dehydrogenase complex See in Reactome R-HSA-70994 ( R-HSA-71403 ) R-HSA-70994 Reaction Name: Succinate <=> Fumarate (with FAD redox reaction on enzyme) See in Reactome
MONDO:0015356	ATM	Q13315	2.7.11.1	R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-9664873 R-HSA-9664873 Reactome Name: Pexophagy See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-6803207 R-HSA-6803207 Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases See in Reactome R-HSA-6803204 R-HSA-6803204 Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5633008 R-HSA-5633008 Reactome Name: TP53 Regulates Transcription of Cell Death Genes See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Cell Cycle Cellular responses to stimuli Gene expression (Transcription) Reproduction Autophagy DNA Repair	R-HSA-3371567 ( R-HSA-3371453 ) R-HSA-3371567 Reaction Name: DBC1 is phosphorylated by ATM/ART See in Reactome R-HSA-349444 ( R-HSA-349425; R-HSA-69541 ) R-HSA-349444 Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM See in Reactome R-HSA-349455 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349455 Reaction Name: Phosphorylation of MDM4 by ATM See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693609 ( R-HSA-2559586; R-HSA-5693565; R-HSA-6804756; R-HSA-69541 ) R-HSA-5693609 Reaction Name: ATM phosphorylates TP53 at S15 See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6798372 ( R-HSA-6804756 ) R-HSA-6798372 Reaction Name: ATM phosphorylates DYRK2 See in Reactome R-HSA-6799097 ( R-HSA-6803204 ) R-HSA-6799097 Reaction Name: ATM phosphorylates ZNF420 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-6800490 ( R-HSA-6803207 ) R-HSA-6800490 Reaction Name: ATM phosphorylates PIDD1 See in Reactome R-HSA-6804276 ( R-HSA-6804760 ) R-HSA-6804276 Reaction Name: ATM phosphorylates TTC5 See in Reactome R-HSA-6804741 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804741 Reaction Name: MDM2 forms homo- or heterodimers See in Reactome R-HSA-6804955 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804955 Reaction Name: ATM phosphorylates MDM2 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9664850 ( R-HSA-9664873 ) R-HSA-9664850 Reaction Name: ATM binds PEX5 See in Reactome R-HSA-9664855 ( R-HSA-9664873 ) R-HSA-9664855 Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 See in Reactome R-HSA-9664862 ( R-HSA-9664873 ) R-HSA-9664862 Reaction Name: ATM dimer:PEX5 phosphorylates PEX5 See in Reactome R-HSA-9664879 ( R-HSA-9664873 ) R-HSA-9664879 Reaction Name: ATM:PEX5 binds ATM See in Reactome R-HSA-9664880 ( R-HSA-9664873 ) R-HSA-9664880 Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 See in Reactome R-HSA-9664881 ( R-HSA-9664873 ) R-HSA-9664881 Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1 See in Reactome R-HSA-9664883 ( R-HSA-9664873 ) R-HSA-9664883 Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane See in Reactome R-HSA-9664888 ( R-HSA-9664873 ) R-HSA-9664888 Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 See in Reactome R-HSA-9664892 ( R-HSA-9664873 ) R-HSA-9664892 Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5 See in Reactome R-HSA-9674127 ( R-HSA-9664873 ) R-HSA-9674127 Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5 See in Reactome R-HSA-9674131 ( R-HSA-9664873 ) R-HSA-9674131 Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5 See in Reactome
MONDO:0015356	ALK	Q9UM73	2.7.10.1	R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome	R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201486 ( R-HSA-201556 ) R-HSA-201486 Reaction Name: ALK binds ligand pleiotrophin (PTN) See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-201519 ( R-HSA-201556 ) R-HSA-201519 Reaction Name: ALK:PTN dimerization See in Reactome R-HSA-201521 ( R-HSA-201556 ) R-HSA-201521 Reaction Name: ALK autophosphorylation downstream of PTN and MDK See in Reactome R-HSA-9667914 ( R-HSA-201556 ) R-HSA-9667914 Reaction Name: ALK binds ligand midkine (MDK) See in Reactome R-HSA-9700137 ( R-HSA-201556 ) R-HSA-9700137 Reaction Name: ALK:MDK dimerization See in Reactome R-HSA-9700142 ( R-HSA-201556 ) R-HSA-9700142 Reaction Name: Active ALK binds FRS2 See in Reactome R-HSA-9700149 ( R-HSA-201556 ) R-HSA-9700149 Reaction Name: Active ALK binds PLCG1 See in Reactome R-HSA-9700154 ( R-HSA-201556 ) R-HSA-9700154 Reaction Name: Active ALK binds SHC1 See in Reactome R-HSA-9700156 ( R-HSA-201556 ) R-HSA-9700156 Reaction Name: Active ALK dimer binds IRS1 See in Reactome R-HSA-9700164 ( R-HSA-201556 ) R-HSA-9700164 Reaction Name: Active ALK phosphorylates FRS2 See in Reactome R-HSA-9700168 ( R-HSA-201556 ) R-HSA-9700168 Reaction Name: Active ALK phosphorylates IRS1 See in Reactome R-HSA-9700171 ( R-HSA-201556 ) R-HSA-9700171 Reaction Name: Active ALK phosphorylates PLCG1 See in Reactome R-HSA-9700175 ( R-HSA-201556 ) R-HSA-9700175 Reaction Name: Active ALK phosphorylates SHC1 See in Reactome R-HSA-9700200 ( R-HSA-201556 ) R-HSA-9700200 Reaction Name: PTPRZ dephosphorylates ligand-bound ALK dimers See in Reactome R-HSA-9700647 ( R-HSA-201556 ) R-HSA-9700647 Reaction Name: Active ALK phosphorylates SRC See in Reactome R-HSA-9700648 ( R-HSA-201556 ) R-HSA-9700648 Reaction Name: Active ALK binds SRC See in Reactome R-HSA-9700662 ( R-HSA-201556 ) R-HSA-9700662 Reaction Name: (PTN/MDK):ALK dimer binds type I ALK-binding TKIs See in Reactome R-HSA-9701485 ( R-HSA-201556 ) R-HSA-9701485 Reaction Name: Active ALK binds JAK3 See in Reactome R-HSA-9701488 ( R-HSA-201556 ) R-HSA-9701488 Reaction Name: Active ALK phosphorylates JAK3 See in Reactome R-HSA-9701507 ( R-HSA-201556 ) R-HSA-9701507 Reaction Name: PTPN6 dephosphorylates JAK3 See in Reactome R-HSA-9701524 ( R-HSA-201556 ) R-HSA-9701524 Reaction Name: STAT3 is phosphorylated downstream of active ALK See in Reactome R-HSA-9725117 ( R-HSA-201556 ) R-HSA-9725117 Reaction Name: ALK gene expression See in Reactome R-HSA-9725315 ( R-HSA-201556 ) R-HSA-9725315 Reaction Name: ALK-stimulated MYCN gene expression See in Reactome
MONDO:0015356	BARD1	Q99728	2.3.2.27	R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins DNA Repair Cell Cycle	R-HSA-5659781 ( R-HSA-5693565 ) R-HSA-5659781 Reaction Name: BRCA1 forms a heterodimer with BARD1 See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5689649 ( R-HSA-5689603 ) R-HSA-5689649 Reaction Name: BAP1 binds BRCA1:BARD1 See in Reactome R-HSA-5691411 ( R-HSA-5689901 ) R-HSA-5691411 Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9700998 ( R-HSA-5693565 ) R-HSA-9700998 Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer See in Reactome R-HSA-9701000 ( R-HSA-5693565 ) R-HSA-9701000 Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates See in Reactome R-HSA-9701003 ( R-HSA-5693565 ) R-HSA-9701003 Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer See in Reactome R-HSA-9707051 ( R-HSA-5693565 ) R-HSA-9707051 Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer See in Reactome
MONDO:0015356	RAD50	Q92878	3.6.-.-	R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Cell Cycle DNA Repair Reproduction	R-HSA-3785768 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-3785768 Reaction Name: MRN complex binds DNA double strand breaks See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682020 ( R-HSA-2559586 ) R-HSA-5682020 Reaction Name: MRN complex binds shortened telomeres See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75172 ( R-HSA-5693548 ) R-HSA-75172 Reaction Name: Formation of RAD50:MRE11 complex See in Reactome R-HSA-75174 ( R-HSA-5693548 ) R-HSA-75174 Reaction Name: Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0015356	CDK4	P11802	2.7.11.22	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-8849470 R-HSA-8849470 Reactome Name: PTK6 Regulates Cell Cycle See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome	R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Gene expression (Transcription) Reproduction Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-1226094 ( R-HSA-69231 ) R-HSA-1226094 Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex See in Reactome R-HSA-1226095 ( R-HSA-69231 ) R-HSA-1226095 Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex See in Reactome R-HSA-182594 ( R-HSA-2559580; R-HSA-2559582; R-HSA-2559585; R-HSA-69231 ) R-HSA-182594 Reaction Name: Association of INK4 family proteins with CDK4/6 See in Reactome R-HSA-3215385 ( R-HSA-3214858 ) R-HSA-3215385 Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 See in Reactome R-HSA-3215426 ( R-HSA-3214858 ) R-HSA-3215426 Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-5216234 ( R-HSA-3214858 ) R-HSA-5216234 Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-5661117 ( R-HSA-3214858 ) R-HSA-5661117 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 See in Reactome R-HSA-69227 ( R-HSA-69231 ) R-HSA-69227 Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-75820 ( R-HSA-75815 ) R-HSA-75820 Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta See in Reactome R-HSA-75822 ( R-HSA-75815 ) R-HSA-75822 Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm See in Reactome R-HSA-8848414 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848414 Reaction Name: Activated PTK6 binds CDKN1B See in Reactome R-HSA-8848436 ( R-HSA-187577; R-HSA-8849470 ) R-HSA-8848436 Reaction Name: PTK6 phosphorylates CDKN1B See in Reactome R-HSA-8941895 ( R-HSA-69231 ) R-HSA-8941895 Reaction Name: Formation of CDK4/6:CCND complexes See in Reactome R-HSA-8941915 ( R-HSA-69231 ) R-HSA-8941915 Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8942803 ( R-HSA-69231 ) R-HSA-8942803 Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus See in Reactome R-HSA-8942836 ( R-HSA-69231 ) R-HSA-8942836 Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 See in Reactome R-HSA-9008412 ( R-HSA-8878166 ) R-HSA-9008412 Reaction Name: CDK4 phosphorylates RUNX2 See in Reactome R-HSA-9018017 ( R-HSA-69231 ) R-HSA-9018017 Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes See in Reactome R-HSA-912429 ( R-HSA-912446 ) R-HSA-912429 Reaction Name: Resolution of meiotic holliday junction See in Reactome R-HSA-912458 ( R-HSA-912446 ) R-HSA-912458 Reaction Name: Formation of meiotic heteroduplex See in Reactome R-HSA-912496 ( R-HSA-912446 ) R-HSA-912496 Reaction Name: Formation of meiotic holliday junction See in Reactome R-HSA-912503 ( R-HSA-912446 ) R-HSA-912503 Reaction Name: Formation of meiotic single-stranded DNA invasion complex See in Reactome R-HSA-9624112 ( R-HSA-9616222 ) R-HSA-9624112 Reaction Name: CEBPA binds CDK4 See in Reactome R-HSA-9754130 ( R-HSA-69231 ) R-HSA-9754130 Reaction Name: CDK4 inhibitors bind CDK4 See in Reactome
MONDO:0015356	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome