DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0013108)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	16
Number of reactions:	56

Search results (Disease ID: MONDO:0013108)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013108	FLT3	P36888	2.7.10.1	R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-9706369 R-HSA-9706369 Reactome Name: Negative regulation of FLT3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Immune System Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6786789 ( R-HSA-9607240 ) R-HSA-6786789 Reaction Name: FLT3LG dimer binds FLT3 See in Reactome R-HSA-8854736 ( R-HSA-9607240 ) R-HSA-8854736 Reaction Name: FLT3LG dimer:FLT3 binds FLT3 See in Reactome R-HSA-9604738 ( R-HSA-9607240 ) R-HSA-9604738 Reaction Name: Active FLT3 dimer binds GRB2 See in Reactome R-HSA-9604767 ( R-HSA-9607240 ) R-HSA-9604767 Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9605259 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9605259 Reaction Name: Active FLT3 binds FYN See in Reactome R-HSA-9606622 ( R-HSA-9607240 ) R-HSA-9606622 Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated See in Reactome R-HSA-9606624 ( R-HSA-9607240 ) R-HSA-9606624 Reaction Name: Active FLT3:GRB2 binds GAB2 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9607224 ( R-HSA-9607240 ) R-HSA-9607224 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 See in Reactome R-HSA-9607301 ( R-HSA-9607240 ) R-HSA-9607301 Reaction Name: Active FLT3:GRB2 binds SOS1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9609274 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9609274 Reaction Name: Active FLT3 binds HCK See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9695828 ( R-HSA-9607240 ) R-HSA-9695828 Reaction Name: FLT3 binds type I TKI See in Reactome R-HSA-9695831 ( R-HSA-9607240 ) R-HSA-9695831 Reaction Name: FLT3 binds type II TKI See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9698408 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9698408 Reaction Name: PTPRJ dephosphorylates active FLT3 See in Reactome R-HSA-9699578 ( R-HSA-9607240 ) R-HSA-9699578 Reaction Name: Active FLT3 phosphorylates CDKN1B See in Reactome R-HSA-9706287 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706287 Reaction Name: Active FLT3 binds to ABL2 See in Reactome R-HSA-9706293 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706293 Reaction Name: Active FLT3 binds to CBL See in Reactome R-HSA-9706298 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706298 Reaction Name: Active FLT3 binds to CSK See in Reactome R-HSA-9706304 ( R-HSA-9607240 ) R-HSA-9706304 Reaction Name: Active FLT3 binds to GRAP2 See in Reactome R-HSA-9706308 ( R-HSA-9607240 ) R-HSA-9706308 Reaction Name: Active FLT3 binds to GRB10 See in Reactome R-HSA-9706312 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome R-HSA-9706315 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706315 Reaction Name: Active FLT3 binds to SH2B3 See in Reactome R-HSA-9706319 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706319 Reaction Name: Active FLT3 binds to SLA See in Reactome R-HSA-9706323 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706323 Reaction Name: Active FLT3 binds to SLA2 See in Reactome R-HSA-9706328 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706328 Reaction Name: Active FLT3 binds to SOCS2 See in Reactome R-HSA-9706330 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706330 Reaction Name: Active FLT3 binds to SOCS6 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9706340 ( R-HSA-9607240 ) R-HSA-9706340 Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1 See in Reactome R-HSA-9706344 ( R-HSA-9607240 ) R-HSA-9706344 Reaction Name: FLT3 phosphorylates GRB10 See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706350 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706350 Reaction Name: FLT3 phosphorylates CBL See in Reactome R-HSA-9706354 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706354 Reaction Name: Ubiquitination of FLT3 See in Reactome R-HSA-9706364 ( R-HSA-9607240; R-HSA-9706369 ) R-HSA-9706364 Reaction Name: Internalization of ubiquitinated FLT3 See in Reactome
MONDO:0013108	SETD2	Q9BYW2	2.1.1.359 2.1.1.-	R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-5638141 ( R-HSA-3214841 ) R-HSA-5638141 Reaction Name: SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) See in Reactome
MONDO:0013108	BCR	P11274	2.7.11.1	R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome	Signal Transduction	R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-9013022 ( R-HSA-9013026 ) R-HSA-9013022 Reaction Name: RHOB GAPs stimulate RHOB GTPase activity See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9013111 ( R-HSA-9013106 ) R-HSA-9013111 Reaction Name: RHOC GAPs stimulate RHOC GTPase activity See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013159 ( R-HSA-9013148 ) R-HSA-9013159 Reaction Name: CDC42 GEFs activate CDC42 See in Reactome R-HSA-9013161 ( R-HSA-9013148 ) R-HSA-9013161 Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity See in Reactome R-HSA-9014295 ( R-HSA-9013404 ) R-HSA-9014295 Reaction Name: RAC2 GAPs stimulate RAC2 GTPase activity See in Reactome R-HSA-9014296 ( R-HSA-9013404 ) R-HSA-9014296 Reaction Name: RAC2 GEFs activate RAC2 See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome