DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0012824)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	9
Number of reactions:	25

Search results (Disease ID: MONDO:0012824)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0012824	POLR3A	O14802	2.7.7.6	R-HSA-76066 R-HSA-76066 Reactome Name: RNA Polymerase III Transcription Initiation From Type 2 Promoter See in Reactome R-HSA-749476 R-HSA-749476 Reactome Name: RNA Polymerase III Abortive And Retractive Initiation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-73980 R-HSA-73980 Reactome Name: RNA Polymerase III Transcription Termination See in Reactome R-HSA-73780 R-HSA-73780 Reactome Name: RNA Polymerase III Chain Elongation See in Reactome R-HSA-76071 R-HSA-76071 Reactome Name: RNA Polymerase III Transcription Initiation From Type 3 Promoter See in Reactome R-HSA-76061 R-HSA-76061 Reactome Name: RNA Polymerase III Transcription Initiation From Type 1 Promoter See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76046 R-HSA-76046 Reactome Name: RNA Polymerase III Transcription Initiation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-74158 R-HSA-74158 Reactome Name: RNA Polymerase III Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-112054 ( R-HSA-749476 ) R-HSA-112054 Reaction Name: RNA Polymerase III Abortive Initiation At Type 3 Open Promoters See in Reactome R-HSA-112055 ( R-HSA-749476 ) R-HSA-112055 Reaction Name: RNA Polymerase III Abortive Initiation At Type 1 Open Promoters See in Reactome R-HSA-112149 ( R-HSA-749476 ) R-HSA-112149 Reaction Name: RNA Polymerase III Abortive Initiation At Type 2 Open Promoters See in Reactome R-HSA-112150 ( R-HSA-749476; R-HSA-76066 ) R-HSA-112150 Reaction Name: RNA Polymerase III Promoter Opening at Type 2 Promoters See in Reactome R-HSA-112152 ( R-HSA-749476; R-HSA-76071 ) R-HSA-112152 Reaction Name: RNA Polymerase III Promoter Opening at Type 3 Promoters See in Reactome R-HSA-112153 ( R-HSA-749476 ) R-HSA-112153 Reaction Name: RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters See in Reactome R-HSA-112155 ( R-HSA-749476 ) R-HSA-112155 Reaction Name: RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters See in Reactome R-HSA-112156 ( R-HSA-749476 ) R-HSA-112156 Reaction Name: RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters See in Reactome R-HSA-113442 ( R-HSA-749476 ) R-HSA-113442 Reaction Name: RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites See in Reactome R-HSA-113446 ( R-HSA-73780 ) R-HSA-113446 Reaction Name: Initiation of RNA Polymerase III Productive Transcription See in Reactome R-HSA-113449 ( R-HSA-73980; R-HSA-749476 ) R-HSA-113449 Reaction Name: RNA Polymerase III Transcriptional Pause at Terminator Sequence See in Reactome R-HSA-113451 ( R-HSA-73780 ) R-HSA-113451 Reaction Name: Resumption of RNA Polymerase III Productive Transcription See in Reactome R-HSA-113454 ( R-HSA-73980; R-HSA-749476 ) R-HSA-113454 Reaction Name: RNA Polymerase III Termination and release of transcribed RNA See in Reactome R-HSA-113705 ( R-HSA-73780; R-HSA-749476 ) R-HSA-113705 Reaction Name: RNA Polymerase III Productive Transcription See in Reactome R-HSA-1964482 ( R-HSA-1834949 ) R-HSA-1964482 Reaction Name: RNA polymerase III transcribes microbial dsDNA to dsRNA See in Reactome R-HSA-76056 ( R-HSA-76061 ) R-HSA-76056 Reaction Name: Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex See in Reactome R-HSA-76060 ( R-HSA-749476; R-HSA-76061 ) R-HSA-76060 Reaction Name: RNA Polymerase III Promoter Opening at Type 1 Promoters See in Reactome R-HSA-83803 ( R-HSA-76071 ) R-HSA-83803 Reaction Name: Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex See in Reactome R-HSA-83805 ( R-HSA-76066 ) R-HSA-83805 Reaction Name: Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex See in Reactome
MONDO:0012824	HSPD1	P10809	5.6.1.7	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-8869496 R-HSA-8869496 Reactome Name: TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Protein localization	R-HSA-1268022 ( R-HSA-1268020 ) R-HSA-1268022 Reaction Name: TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space See in Reactome R-HSA-1299475 ( R-HSA-1268020 ) R-HSA-1299475 Reaction Name: TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix See in Reactome R-HSA-1299478 ( R-HSA-1268020 ) R-HSA-1299478 Reaction Name: MPP cleaves targeting peptide (presequence) of matrix precursors See in Reactome R-HSA-1299480 ( R-HSA-1268020 ) R-HSA-1299480 Reaction Name: Precursor proteins enter TIMM23 PAM See in Reactome R-HSA-8869558 ( R-HSA-8869496 ) R-HSA-8869558 Reaction Name: HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome