DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0011613)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	6

Search results (Disease ID: MONDO:0011613)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011613	PINK1	Q9BXM7	2.7.11.1	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription)	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205661 ( R-HSA-5205685 ) R-HSA-5205661 Reaction Name: Pink1 is recruited from the cytoplasm to the mitochondria See in Reactome R-HSA-5205672 ( R-HSA-5205685 ) R-HSA-5205672 Reaction Name: Uncleaved Pink1 accumulates in damaged mitochondria See in Reactome R-HSA-5205681 ( R-HSA-5205685 ) R-HSA-5205681 Reaction Name: Pink1 is cleaved on healthy mitochondria See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9621289 ( R-HSA-9614657 ) R-HSA-9621289 Reaction Name: PINK1 gene expression is stimulated by FOXO1,FOXO3 See in Reactome