DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011551	TH	P07101	1.14.16.2	R-HSA-209905 R-HSA-209905 Reactome Name: Catecholamine biosynthesis See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-209776 R-HSA-209776 Reactome Name: Metabolism of amine-derived hormones See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-209823 ( R-HSA-209905 ) R-HSA-209823 Reaction Name: Tyrosine is hydroxylated to dopa See in Reactome
MONDO:0011551	GCH1	P30793	3.5.4.16	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-1474146 ( R-HSA-1474151 ) R-HSA-1474146 Reaction Name: GCH1 reduces GTP to dihydroneopterin triphosphate See in Reactome R-HSA-1474158 ( R-HSA-1474151 ) R-HSA-1474158 Reaction Name: GCHFR binds to GCH1 and negatively regulates its activity See in Reactome