DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0011225)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	1
Number of reactions:	9

Search results (Disease ID: MONDO:0011225)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011225	DCLRE1C	Q96SD1	3.1.-.-	R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	DNA Repair	R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5686924 ( R-HSA-5693571 ) R-HSA-5686924 Reaction Name: DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs See in Reactome R-HSA-5687183 ( R-HSA-5693571 ) R-HSA-5687183 Reaction Name: PRKDC phosphorylates DCLRE1C at DNA DSBs See in Reactome R-HSA-5687360 ( R-HSA-5693571 ) R-HSA-5687360 Reaction Name: POLL or POLM extends aligned DNA DSB ends to fill gaps See in Reactome R-HSA-5693533 ( R-HSA-5693571 ) R-HSA-5693533 Reaction Name: DCLRE1C (ARTEMIS) processes DNA DSB ends See in Reactome R-HSA-5693574 ( R-HSA-5693571 ) R-HSA-5693574 Reaction Name: XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ See in Reactome R-HSA-5693578 ( R-HSA-5693571 ) R-HSA-5693578 Reaction Name: TDP1 and TDP2 process unligatable DSB ends See in Reactome R-HSA-5693604 ( R-HSA-5693571 ) R-HSA-5693604 Reaction Name: XRCC4:LIG4 ligates DNA DSB ends during NHEJ See in Reactome
MONDO:0011225	LIG4	P49917	6.5.1.1	R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome	DNA Repair	R-HSA-5687360 ( R-HSA-5693571 ) R-HSA-5687360 Reaction Name: POLL or POLM extends aligned DNA DSB ends to fill gaps See in Reactome R-HSA-5693574 ( R-HSA-5693571 ) R-HSA-5693574 Reaction Name: XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ See in Reactome R-HSA-5693604 ( R-HSA-5693571 ) R-HSA-5693604 Reaction Name: XRCC4:LIG4 ligates DNA DSB ends during NHEJ See in Reactome