DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0010961)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	5
Number of reactions:	5

Search results (Disease ID: MONDO:0010961)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010961	PCSK1	P29120	3.4.21.93	R-HSA-264876 R-HSA-264876 Reactome Name: Insulin processing See in Reactome R-HSA-422085 R-HSA-422085 Reactome Name: Synthesis, secretion, and deacylation of Ghrelin See in Reactome R-HSA-381771 R-HSA-381771 Reactome Name: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) See in Reactome R-HSA-400511 R-HSA-400511 Reactome Name: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) See in Reactome R-HSA-209952 R-HSA-209952 Reactome Name: Peptide hormone biosynthesis See in Reactome	R-HSA-400508 R-HSA-400508 Reactome Name: Incretin synthesis, secretion, and inactivation See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-265301 ( R-HSA-209952 ) R-HSA-265301 Reaction Name: Corticotropin cleavage from POMC See in Reactome R-HSA-381798 ( R-HSA-381771 ) R-HSA-381798 Reaction Name: PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 See in Reactome R-HSA-400492 ( R-HSA-400511 ) R-HSA-400492 Reaction Name: PCSK1 hydrolyzes proGIP to GIP See in Reactome R-HSA-422021 ( R-HSA-422085 ) R-HSA-422021 Reaction Name: PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin See in Reactome R-HSA-9023196 ( R-HSA-264876 ) R-HSA-9023196 Reaction Name: PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) See in Reactome