DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0010214)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	3
Number of reactions:	13

Search results (Disease ID: MONDO:0010214)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010214	POLH	Q9Y253	2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair	R-HSA-110316 ( R-HSA-110320 ) R-HSA-110316 Reaction Name: POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template See in Reactome R-HSA-110317 ( R-HSA-110320 ) R-HSA-110317 Reaction Name: Insertion of correct bases opposite the lesion by POLH See in Reactome R-HSA-110319 ( R-HSA-110320 ) R-HSA-110319 Reaction Name: Elongation by POLH See in Reactome R-HSA-5653754 ( R-HSA-5656169 ) R-HSA-5653754 Reaction Name: UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA See in Reactome R-HSA-5653756 ( R-HSA-5656169 ) R-HSA-5653756 Reaction Name: TRIM25 binds monoUb:164-PCNA See in Reactome R-HSA-5653766 ( R-HSA-5656169 ) R-HSA-5653766 Reaction Name: USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA See in Reactome R-HSA-5653770 ( R-HSA-5656169 ) R-HSA-5653770 Reaction Name: USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654986 ( R-HSA-110320 ) R-HSA-5654986 Reaction Name: SPRTN binds monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5655142 ( R-HSA-110320 ) R-HSA-5655142 Reaction Name: RCHY1 binds POLH See in Reactome R-HSA-5655170 ( R-HSA-110320 ) R-HSA-5655170 Reaction Name: RCHY1 monoubiquitinates POLH See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome