DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0009863)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	2
Number of reactions:	5

Search results (Disease ID: MONDO:0009863)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009863	PTS	Q03393	4.2.3.12	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-1474184 ( R-HSA-1474151 ) R-HSA-1474184 Reaction Name: DHNTP is dephosphorylated by PTPS to PTHP See in Reactome R-HSA-1475422 ( R-HSA-1474151 ) R-HSA-1475422 Reaction Name: PTPS is phosphorylated by cGMP-dependant protein kinase II See in Reactome
MONDO:0009863	PAH	P00439	1.14.16.1	R-HSA-8964208 R-HSA-8964208 Reactome Name: Phenylalanine metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963691 R-HSA-8963691 Reactome Name: Phenylalanine and tyrosine metabolism See in Reactome	Metabolism	R-HSA-71118 ( R-HSA-8964208 ) R-HSA-71118 Reaction Name: PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr See in Reactome
MONDO:0009863	GCH1	P30793	3.5.4.16	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-1474146 ( R-HSA-1474151 ) R-HSA-1474146 Reaction Name: GCH1 reduces GTP to dihydroneopterin triphosphate See in Reactome R-HSA-1474158 ( R-HSA-1474151 ) R-HSA-1474158 Reaction Name: GCHFR binds to GCH1 and negatively regulates its activity See in Reactome