DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0009300)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	9
Number of reactions:	18

Search results (Disease ID: MONDO:0009300)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009300	PRORP	O15091	3.1.26.5	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome
MONDO:0009300	HSD17B4	P51659	1.1.1.n12 4.2.1.119 4.2.1.107	R-HSA-389887 R-HSA-389887 Reactome Name: Beta-oxidation of pristanoyl-CoA See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-9033500 R-HSA-9033500 Reactome Name: TYSND1 cleaves peroxisomal proteins See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Protein localization Metabolism	R-HSA-192331 ( R-HSA-193368 ) R-HSA-192331 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-193455 ( R-HSA-193368 ) R-HSA-193455 Reaction Name: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193508 ( R-HSA-193368 ) R-HSA-193508 Reaction Name: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193535 ( R-HSA-193368 ) R-HSA-193535 Reaction Name: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-2066778 ( R-HSA-2046106 ) R-HSA-2066778 Reaction Name: Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-2066780 ( R-HSA-2046106 ) R-HSA-2066780 Reaction Name: Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-389986 ( R-HSA-389887 ) R-HSA-389986 Reaction Name: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA See in Reactome R-HSA-389995 ( R-HSA-389887 ) R-HSA-389995 Reaction Name: 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ See in Reactome R-HSA-390251 ( R-HSA-390247 ) R-HSA-390251 Reaction Name: HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-390252 ( R-HSA-390247 ) R-HSA-390252 Reaction Name: HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome R-HSA-9033530 ( R-HSA-9033241; R-HSA-9033500 ) R-HSA-9033530 Reaction Name: TYSND1 cleaves HSD17B4 See in Reactome