DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0008542)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	8
Number of reactions:	69

Search results (Disease ID: MONDO:0008542)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008542	EPHB4	P54760	2.7.10.1	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome	R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Developmental Biology	R-HSA-3928578 ( R-HSA-2682334 ) R-HSA-3928578 Reaction Name: EPH receptors autophosphorylate See in Reactome R-HSA-3928580 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928580 Reaction Name: SFKs phosphorylate EFNBs See in Reactome R-HSA-3928583 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928583 Reaction Name: FYN phosphorylates NMDAR2B See in Reactome R-HSA-3928584 ( R-HSA-2682334 ) R-HSA-3928584 Reaction Name: p-EPHs bind SRC,FYN,YES,LYN See in Reactome R-HSA-3928588 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928588 Reaction Name: EPHBs binds PTK2 See in Reactome R-HSA-3928591 ( R-HSA-2682334 ) R-HSA-3928591 Reaction Name: EPH:EFN tetramers oligomerise See in Reactome R-HSA-3928592 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928594 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928594 Reaction Name: SFKs phosphorylate GIT1 See in Reactome R-HSA-3928595 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928595 Reaction Name: N-WASP binds ARP2/3 and G-actin See in Reactome R-HSA-3928597 ( R-HSA-2682334 ) R-HSA-3928597 Reaction Name: EPH:EFN dimers tetramerise See in Reactome R-HSA-3928598 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928598 Reaction Name: Recruitment of p190RhoGEF to p-FAK See in Reactome R-HSA-3928600 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928600 Reaction Name: N-WASP binds ITSN1 See in Reactome R-HSA-3928601 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928601 Reaction Name: CDC42 and PIP2 bind WASL, activating it See in Reactome R-HSA-3928604 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928604 Reaction Name: SFKs phosphorylate VAV2,3 See in Reactome R-HSA-3928607 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928607 Reaction Name: p-EPHs bind VAV2,3 See in Reactome R-HSA-3928610 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928610 Reaction Name: PTK2 autophosphorylates at Y397 See in Reactome R-HSA-3928612 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928614 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928614 Reaction Name: EFNB:GRB4 binds GIT1 See in Reactome R-HSA-3928615 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928615 Reaction Name: EFNBs bind SFKs See in Reactome R-HSA-3928617 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928617 Reaction Name: EPHB2 binds KALRN See in Reactome R-HSA-3928623 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928623 Reaction Name: EPHBs bind NMDARs See in Reactome R-HSA-3928624 ( R-HSA-2682334 ) R-HSA-3928624 Reaction Name: EPHBs bind EFNBs See in Reactome R-HSA-3928625 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928627 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928627 Reaction Name: EPHB phosphorylates TIAM1 See in Reactome R-HSA-3928628 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928631 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928631 Reaction Name: GIT1 binds bPIX See in Reactome R-HSA-3928632 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928632 Reaction Name: ITSN1 exchanges GTP for GDP on CDC42, activating it See in Reactome R-HSA-3928633 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928639 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928639 Reaction Name: p-EFNB binds GRB4 See in Reactome R-HSA-3928640 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928644 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928644 Reaction Name: EPHB binds ITSN1 See in Reactome R-HSA-3928645 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-3928645 Reaction Name: EPHB:NMDAR binds TIAM1 See in Reactome R-HSA-3928654 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928654 Reaction Name: Clathrin internalises EPH:EFN complexes See in Reactome R-HSA-3928656 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-3928657 ( R-HSA-2682334; R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-4093329 ( R-HSA-2682334; R-HSA-3928664 ) R-HSA-4093329 Reaction Name: EFNBs bind SDCBP See in Reactome R-HSA-4093330 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093330 Reaction Name: EPHB binds p120-RasGAP See in Reactome R-HSA-4093331 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093332 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093332 Reaction Name: p-EPHB phosphorylates SDC2 See in Reactome R-HSA-4093336 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-4093339 ( R-HSA-2682334; R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome
MONDO:0008542	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome
MONDO:0008542	FLT4	P35916	2.7.10.1	R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-194308 ( R-HSA-195399 ) R-HSA-194308 Reaction Name: VEGF-C,D bind to VEGFR3 leading to receptor dimerization See in Reactome R-HSA-9604471 ( R-HSA-9013695 ) R-HSA-9604471 Reaction Name: FLT4 gene expression is stimulated by NOTCH4 See in Reactome