DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0007958)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	12
Number of reactions:	55

Search results (Disease ID: MONDO:0007958)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007958	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0007958	RET	P07949	2.7.10.1	R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8853734 ( R-HSA-8853659 ) R-HSA-8853734 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 See in Reactome R-HSA-8853737 ( R-HSA-8853659 ) R-HSA-8853737 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 See in Reactome R-HSA-8853745 ( R-HSA-8853659 ) R-HSA-8853745 Reaction Name: RET binds GFRA1,GFRA3 See in Reactome R-HSA-8853753 ( R-HSA-8853659 ) R-HSA-8853753 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 See in Reactome R-HSA-8853755 ( R-HSA-8853659 ) R-HSA-8853755 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 See in Reactome R-HSA-8853762 ( R-HSA-8853659 ) R-HSA-8853762 Reaction Name: RET dimerizes See in Reactome R-HSA-8853774 ( R-HSA-8853659 ) R-HSA-8853774 Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated See in Reactome R-HSA-8853789 ( R-HSA-8853659 ) R-HSA-8853789 Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2 See in Reactome R-HSA-8853792 ( R-HSA-8853659 ) R-HSA-8853792 Reaction Name: RET tyrosine phosphorylation See in Reactome R-HSA-8853793 ( R-HSA-8853659 ) R-HSA-8853793 Reaction Name: p-5Y-RET complexes bind GRB2 See in Reactome R-HSA-8853800 ( R-HSA-8853659 ) R-HSA-8853800 Reaction Name: ARTN binds RET:GFRA1,GFRA3 See in Reactome R-HSA-8853801 ( R-HSA-8853659 ) R-HSA-8853801 Reaction Name: PSPN binds RET:GFRA4 See in Reactome R-HSA-8854897 ( R-HSA-8853659 ) R-HSA-8854897 Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 See in Reactome R-HSA-8854899 ( R-HSA-8853659 ) R-HSA-8854899 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8854981 ( R-HSA-8853659 ) R-HSA-8854981 Reaction Name: SHC1 in the RET complex is phosphorylated See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8855564 ( R-HSA-8853659 ) R-HSA-8855564 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 See in Reactome R-HSA-8855617 ( R-HSA-8853659 ) R-HSA-8855617 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 See in Reactome R-HSA-8855747 ( R-HSA-8853659 ) R-HSA-8855747 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome R-HSA-8871226 ( R-HSA-8853659 ) R-HSA-8871226 Reaction Name: RET binds GFRA1,GFRA2 See in Reactome R-HSA-8871227 ( R-HSA-8853659 ) R-HSA-8871227 Reaction Name: RET binds GFRA4 See in Reactome