DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0007915)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	6
Number of reactions:	8

Search results (Disease ID: MONDO:0007915)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007915	BLK	P51451	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-8939245 R-HSA-8939245 Reactome Name: RUNX1 regulates transcription of genes involved in BCR signaling See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System	R-HSA-8938987 ( R-HSA-8939245 ) R-HSA-8938987 Reaction Name: BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 See in Reactome R-HSA-983709 ( R-HSA-983695 ) R-HSA-983709 Reaction Name: LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) See in Reactome
MONDO:0007915	PTPN22	Q9Y2R2	3.1.3.48	R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome R-HSA-202427 R-HSA-202427 Reactome Name: Phosphorylation of CD3 and TCR zeta chains See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-8852200 ( R-HSA-202427 ) R-HSA-8852200 Reaction Name: Inactivation of LCK by PTPN22 See in Reactome R-HSA-8855375 ( R-HSA-202427 ) R-HSA-8855375 Reaction Name: PTPN22 dissociates from CSK See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome
MONDO:0007915	TREX1	Q9NSU2	3.1.11.2	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-3248023 R-HSA-3248023 Reactome Name: Regulation by TREX1 See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3244605 ( R-HSA-3248023 ) R-HSA-3244605 Reaction Name: TREX1 binds retroviral-derived DNA See in Reactome R-HSA-3245943 ( R-HSA-3248023 ) R-HSA-3245943 Reaction Name: Viral DNA cleavage by TREX1 See in Reactome