DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0007576)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	10
Number of reactions:	16

Search results (Disease ID: MONDO:0007576)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007576	ALOX12	P18054	1.13.11.- 1.13.11.33 3.3.2.- 1.13.11.31	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome R-HSA-9025106 R-HSA-9025106 Reactome Name: Biosynthesis of DPAn-6 SPMs See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-9026290 R-HSA-9026290 Reactome Name: Biosynthesis of DPAn-3-derived maresins See in Reactome R-HSA-2142696 R-HSA-2142696 Reactome Name: Synthesis of Hepoxilins (HX) and Trioxilins (TrX) See in Reactome	R-HSA-9025094 R-HSA-9025094 Reactome Name: Biosynthesis of DPAn-3 SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018683 R-HSA-9018683 Reactome Name: Biosynthesis of DPA-derived SPMs See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-2161775 ( R-HSA-2142700 ) R-HSA-2161775 Reaction Name: ALOX12 oxidises LTA4 to LXA4/B4 See in Reactome R-HSA-2161794 ( R-HSA-2142696 ) R-HSA-2161794 Reaction Name: Arachidonic acid is converted to HXA3/B3 by ALOX12 See in Reactome R-HSA-2161948 ( R-HSA-2142712 ) R-HSA-2161948 Reaction Name: Arachidonic acid is converted to 12-oxoETE by ALOX12 See in Reactome R-HSA-2161964 ( R-HSA-2142712 ) R-HSA-2161964 Reaction Name: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 See in Reactome R-HSA-9020274 ( R-HSA-9018677 ) R-HSA-9020274 Reaction Name: ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA See in Reactome R-HSA-9024983 ( R-HSA-9018677 ) R-HSA-9024983 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA See in Reactome R-HSA-9025957 ( R-HSA-9025106 ) R-HSA-9025957 Reaction Name: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 See in Reactome R-HSA-9026006 ( R-HSA-9026290 ) R-HSA-9026006 Reaction Name: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 See in Reactome R-HSA-9026007 ( R-HSA-9026290 ) R-HSA-9026007 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 See in Reactome
MONDO:0007576	RNF6	Q9Y252	2.3.2.27	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0007576	WWOX	Q9NZC7	1.1.1.-	R-HSA-8866904 R-HSA-8866904 Reactome Name: Negative regulation of activity of TFAP2 (AP-2) family transcription factors See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome	R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1253343 ( R-HSA-1251985 ) R-HSA-1253343 Reaction Name: WWOX binds ERBB4s80 See in Reactome R-HSA-8864569 ( R-HSA-8866904 ) R-HSA-8864569 Reaction Name: WWOX binds TFAP2C See in Reactome R-HSA-8864577 ( R-HSA-8866907 ) R-HSA-8864577 Reaction Name: TFAP2C translocates to the nucleus See in Reactome