DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0005148)

Number of enzymes:	9
Number of disease:	1
Number of reactomes:	50
Number of reactions:	81

Search results (Disease ID: MONDO:0005148)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	MT-ND1	P03886	7.1.1.2	R-HSA-6799198 R-HSA-6799198 Reactome Name: Complex I biogenesis See in Reactome R-HSA-611105 R-HSA-611105 Reactome Name: Respiratory electron transport See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-163200 R-HSA-163200 Reactome Name: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. See in Reactome	Metabolism	R-HSA-163217 ( R-HSA-611105 ) R-HSA-163217 Reaction Name: Complex I oxidises NADH to NAD+, reduces CoQ to QH2 See in Reactome R-HSA-6799179 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799179 Reaction Name: Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex See in Reactome R-HSA-6799191 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799191 Reaction Name: Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex See in Reactome R-HSA-6799196 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799196 Reaction Name: The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I See in Reactome R-HSA-6799197 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799197 Reaction Name: ND4, ND5 bind the 550kDa complex to form the 815kDa complex See in Reactome R-HSA-6799202 ( R-HSA-611105; R-HSA-6799198 ) R-HSA-6799202 Reaction Name: The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex See in Reactome
MONDO:0005148	GPD2	P43304	1.1.5.3	R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-1483166 R-HSA-1483166 Reactome Name: Synthesis of PA See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome	Metabolism	R-HSA-188467 ( R-HSA-1483166; R-HSA-163560 ) R-HSA-188467 Reaction Name: Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) See in Reactome
MONDO:0005148	ENPP1	P22413	3.6.1.9 3.1.4.1	R-HSA-196843 R-HSA-196843 Reactome Name: Vitamin B2 (riboflavin) metabolism See in Reactome R-HSA-199220 R-HSA-199220 Reactome Name: Vitamin B5 (pantothenate) metabolism See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-196955 ( R-HSA-196843 ) R-HSA-196955 Reaction Name: 2xENPP1 hydrolyzes FAD to FMN See in Reactome R-HSA-8938314 ( R-HSA-199220 ) R-HSA-8938314 Reaction Name: ENPPs hydrolyse CoA-SH to PPANT, PAP See in Reactome
MONDO:0005148	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0005148	CDKAL1	Q5VV42	2.8.4.5	R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6786571 ( R-HSA-6782315 ) R-HSA-6786571 Reaction Name: CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 See in Reactome
MONDO:0005148	INSR	P06213	2.7.10.1	R-HSA-74713 R-HSA-74713 Reactome Name: IRS activation See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome	Signal Transduction	R-HSA-110011 ( R-HSA-74749; R-HSA-74751; R-HSA-74752 ) R-HSA-110011 Reaction Name: Binding of Grb10 to the insulin receptor See in Reactome R-HSA-74707 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74707 Reaction Name: Binding of IRS to insulin receptor See in Reactome R-HSA-74711 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74711 Reaction Name: Phosphorylation of IRS See in Reactome R-HSA-74712 ( R-HSA-74713; R-HSA-74751; R-HSA-74752 ) R-HSA-74712 Reaction Name: Dissociation of IRS-P from insulin receptor See in Reactome R-HSA-74715 ( R-HSA-74752 ) R-HSA-74715 Reaction Name: Autophosphorylation of insulin receptor See in Reactome R-HSA-74716 ( R-HSA-74752 ) R-HSA-74716 Reaction Name: Insulin binds the insulin receptor See in Reactome R-HSA-74718 ( R-HSA-74752 ) R-HSA-74718 Reaction Name: Internalisation of the insulin receptor See in Reactome R-HSA-74726 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74726 Reaction Name: Dissociation of insulin from insulin receptor See in Reactome R-HSA-74733 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74733 Reaction Name: Insulin receptor de-phosphorylation See in Reactome R-HSA-74734 ( R-HSA-74752; R-HSA-77387 ) R-HSA-74734 Reaction Name: Re-integration of insulin receptor into plasma membrane See in Reactome R-HSA-74740 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74740 Reaction Name: Binding of SHC1 to insulin receptor See in Reactome R-HSA-74742 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74742 Reaction Name: Phosphorylation of SHC1 See in Reactome R-HSA-74743 ( R-HSA-74751; R-HSA-74752 ) R-HSA-74743 Reaction Name: Dissociation of p-Y427-SHC1 from insulin receptor See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome
MONDO:0005148	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0005148	SLC2A4	P14672	-	R-HSA-189200 R-HSA-189200 Reactome Name: Cellular hexose transport See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Developmental Biology Transport of small molecules Vesicle-mediated transport	R-HSA-1183032 ( R-HSA-381340 ) R-HSA-1183032 Reaction Name: Expression of GLUT4 See in Reactome R-HSA-1449574 ( R-HSA-1445148 ) R-HSA-1449574 Reaction Name: SLC2A4 (GLUT4) vesicle fuses with the plasma membrane See in Reactome R-HSA-8981570 ( R-HSA-189200 ) R-HSA-8981570 Reaction Name: GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol See in Reactome
MONDO:0005148	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158; R-HSA-74751; R-HSA-74752 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158; R-HSA-74751; R-HSA-74752 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160; R-HSA-74751; R-HSA-74752 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome