DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0005090)

Number of enzymes:	4
Number of disease:	1
Number of reactomes:	8
Number of reactions:	13

Search results (Disease ID: MONDO:0005090)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005090	DAO	P14920	1.4.3.3	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-389821 ( R-HSA-389661 ) R-HSA-389821 Reaction Name: glycine + O2 => glyoxylate + H2O2 + NH4+ See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0005090	COMT	P21964	2.1.1.6	R-HSA-379398 R-HSA-379398 Reactome Name: Enzymatic degradation of Dopamine by monoamine oxidase See in Reactome R-HSA-379397 R-HSA-379397 Reactome Name: Enzymatic degradation of dopamine by COMT See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-379401 R-HSA-379401 Reactome Name: Dopamine clearance from the synaptic cleft See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-112311 R-HSA-112311 Reactome Name: Neurotransmitter clearance See in Reactome	Metabolism Neuronal System	R-HSA-175983 ( R-HSA-156581 ) R-HSA-175983 Reaction Name: COMT transfer CH3 from AdoMet to 3,4DHBNZ See in Reactome R-HSA-379387 ( R-HSA-379397 ) R-HSA-379387 Reaction Name: COMT transfers Met to DA to form 3MT See in Reactome R-HSA-379464 ( R-HSA-379398 ) R-HSA-379464 Reaction Name: COMT transfers Met to DOPAC to form HVA See in Reactome R-HSA-9679775 ( R-HSA-379397 ) R-HSA-9679775 Reaction Name: COMT binds COMT Inhibitors See in Reactome
MONDO:0005090	MTHFR	P42898	1.5.1.20	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200676 ( R-HSA-196757 ) R-HSA-200676 Reaction Name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG See in Reactome
MONDO:0005090	SMARCA2	P51531	3.6.4.-	R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Gene expression (Transcription) Chromatin organization	R-HSA-3215448 ( R-HSA-3214858 ) R-HSA-3215448 Reaction Name: SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity See in Reactome R-HSA-5205799 ( R-HSA-3214858 ) R-HSA-5205799 Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) See in Reactome R-HSA-5205861 ( R-HSA-3214858 ) R-HSA-5205861 Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) See in Reactome R-HSA-8938217 ( R-HSA-8939243 ) R-HSA-8938217 Reaction Name: RUNX1 binds the SWI/SNF complex See in Reactome