MONDO:0005061 |
EPHA5 |
P54756 |
2.7.10.1
|
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-2682334
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-422475
R-HSA-9675108
R-HSA-1266738
|
Developmental Biology
|
R-HSA-3928578
(
R-HSA-2682334
)
R-HSA-3928578
Reaction Name: EPH receptors autophosphorylate
See in Reactome
R-HSA-3928584
(
R-HSA-2682334
)
R-HSA-3928591
(
R-HSA-2682334
)
R-HSA-3928597
(
R-HSA-2682334
)
R-HSA-3928602
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928604
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928607
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928642
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928646
(
R-HSA-2682334
)
R-HSA-3928648
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-3928660
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-4093327
(
R-HSA-2682334;
R-HSA-3928665
)
|
MONDO:0005061 |
DNMT3A |
Q9Y6K1 |
2.1.1.37
2.1.1.-
|
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-4655427
R-HSA-4655427
Reactome Name: SUMOylation of DNA methylation proteins
See in Reactome
R-HSA-212300
R-HSA-212300
Reactome Name: PRC2 methylates histones and DNA
See in Reactome
R-HSA-5334118
|
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-392499
R-HSA-4839726
R-HSA-2990846
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3247509
|
Gene expression (Transcription)
Metabolism of proteins
Chromatin organization
|
R-HSA-212222
(
R-HSA-212300
)
R-HSA-212222
Reaction Name: PRC2 recruits DNA methyltransferases
See in Reactome
R-HSA-212269
(
R-HSA-212300
)
R-HSA-212269
Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
See in Reactome
R-HSA-4655440
(
R-HSA-4655427
)
R-HSA-4655440
Reaction Name: CBX4 (Pc2) SUMOylates DNMT3A with SUMO1
See in Reactome
R-HSA-5212679
(
R-HSA-3214858
)
R-HSA-5334152
(
R-HSA-5334118
)
R-HSA-5334152
Reaction Name: DNMT3A:DNMT3L methylates cytosine in DNA
See in Reactome
R-HSA-5334179
(
R-HSA-5334118
)
|
MONDO:0005061 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005061 |
ARAF |
P10398 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5674135
R-HSA-5673000
|
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-5673001
|
Signal Transduction
|
R-HSA-5672950
(
R-HSA-5673000
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000
)
R-HSA-5672960
(
R-HSA-5673000
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9653108
(
R-HSA-5673000
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005061 |
BRAF |
P15056 |
2.7.11.1
|
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-187706
R-HSA-187706
Reactome Name: Signalling to p38 via RIT and RIN
See in Reactome
R-HSA-170968
R-HSA-5674135
R-HSA-170984
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-5673000
|
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-5654738
R-HSA-187687
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-5654736
R-HSA-190236
R-HSA-5654741
R-HSA-5684996
R-HSA-5654743
R-HSA-187037
R-HSA-5673001
|
Signal Transduction
|
R-HSA-1295604
(
R-HSA-1295596
)
R-HSA-1295604
Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2
See in Reactome
R-HSA-1295634
(
R-HSA-1295596
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-169901
(
R-HSA-170984
)
R-HSA-169901
Reaction Name: Rap1-GTP complex binds BRAF complex
See in Reactome
R-HSA-170965
(
R-HSA-170968
)
R-HSA-170965
Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf
See in Reactome
R-HSA-187698
(
R-HSA-187706
)
R-HSA-5672950
(
R-HSA-5673000
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672951
(
R-HSA-5673000
)
R-HSA-5672960
(
R-HSA-5673000
)
R-HSA-5672960
Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF
See in Reactome
R-HSA-5672961
(
R-HSA-5673000
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5672966
(
R-HSA-5673000
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674140
(
R-HSA-5675221
)
R-HSA-5675198
(
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675417
(
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610163
(
R-HSA-170968
)
R-HSA-9610163
Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF
See in Reactome
R-HSA-9612980
(
R-HSA-170984
)
R-HSA-9612980
Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
See in Reactome
R-HSA-9653108
(
R-HSA-5673000
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658445
(
R-HSA-5673000
)
R-HSA-9658445
Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
See in Reactome
|
MONDO:0005061 |
ALK |
Q9UM73 |
2.7.10.1
|
R-HSA-201556
|
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
|
Signal Transduction
|
R-HSA-201486
(
R-HSA-201556
)
R-HSA-201486
Reaction Name: ALK binds ligand pleiotrophin (PTN)
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-201519
(
R-HSA-201556
)
R-HSA-201521
(
R-HSA-201556
)
R-HSA-201521
Reaction Name: ALK autophosphorylation downstream of PTN and MDK
See in Reactome
R-HSA-9667914
(
R-HSA-201556
)
R-HSA-9667914
Reaction Name: ALK binds ligand midkine (MDK)
See in Reactome
R-HSA-9700137
(
R-HSA-201556
)
R-HSA-9700142
(
R-HSA-201556
)
R-HSA-9700149
(
R-HSA-201556
)
R-HSA-9700154
(
R-HSA-201556
)
R-HSA-9700156
(
R-HSA-201556
)
R-HSA-9700164
(
R-HSA-201556
)
R-HSA-9700164
Reaction Name: Active ALK phosphorylates FRS2
See in Reactome
R-HSA-9700168
(
R-HSA-201556
)
R-HSA-9700168
Reaction Name: Active ALK phosphorylates IRS1
See in Reactome
R-HSA-9700171
(
R-HSA-201556
)
R-HSA-9700171
Reaction Name: Active ALK phosphorylates PLCG1
See in Reactome
R-HSA-9700175
(
R-HSA-201556
)
R-HSA-9700175
Reaction Name: Active ALK phosphorylates SHC1
See in Reactome
R-HSA-9700200
(
R-HSA-201556
)
R-HSA-9700200
Reaction Name: PTPRZ dephosphorylates ligand-bound ALK dimers
See in Reactome
R-HSA-9700647
(
R-HSA-201556
)
R-HSA-9700648
(
R-HSA-201556
)
R-HSA-9700662
(
R-HSA-201556
)
R-HSA-9700662
Reaction Name: (PTN/MDK):ALK dimer binds type I ALK-binding TKIs
See in Reactome
R-HSA-9701485
(
R-HSA-201556
)
R-HSA-9701488
(
R-HSA-201556
)
R-HSA-9701488
Reaction Name: Active ALK phosphorylates JAK3
See in Reactome
R-HSA-9701507
(
R-HSA-201556
)
R-HSA-9701524
(
R-HSA-201556
)
R-HSA-9701524
Reaction Name: STAT3 is phosphorylated downstream of active ALK
See in Reactome
R-HSA-9725117
(
R-HSA-201556
)
R-HSA-9725315
(
R-HSA-201556
)
R-HSA-9725315
Reaction Name: ALK-stimulated MYCN gene expression
See in Reactome
|
MONDO:0005061 |
CDK4 |
P11802 |
2.7.11.22
|
R-HSA-2559585
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-381340
R-HSA-381340
Reactome Name: Transcriptional regulation of white adipocyte differentiation
See in Reactome
R-HSA-912446
R-HSA-9616222
R-HSA-9616222
Reactome Name: Transcriptional regulation of granulopoiesis
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-8849470
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
|
R-HSA-8848021
R-HSA-2559583
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-74160
R-HSA-2262752
R-HSA-69236
R-HSA-69278
R-HSA-1474165
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-8953897
R-HSA-3247509
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-69242
R-HSA-1500620
R-HSA-4839726
R-HSA-162582
|
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Reproduction
Cellular responses to stimuli
Chromatin organization
Signal Transduction
|
R-HSA-1226094
(
R-HSA-69231
)
R-HSA-1226094
Reaction Name: Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
See in Reactome
R-HSA-1226095
(
R-HSA-69231
)
R-HSA-1226095
Reaction Name: Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
See in Reactome
R-HSA-182594
(
R-HSA-2559580;
R-HSA-2559582;
R-HSA-2559585;
R-HSA-69231
)
R-HSA-182594
Reaction Name: Association of INK4 family proteins with CDK4/6
See in Reactome
R-HSA-3215385
(
R-HSA-3214858
)
R-HSA-3215385
Reaction Name: CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77
See in Reactome
R-HSA-3215426
(
R-HSA-3214858
)
R-HSA-3215426
Reaction Name: COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77
See in Reactome
R-HSA-5205799
(
R-HSA-3214858
)
R-HSA-5205799
Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
See in Reactome
R-HSA-5205861
(
R-HSA-3214858
)
R-HSA-5205861
Reaction Name: COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
See in Reactome
R-HSA-5216234
(
R-HSA-3214858
)
R-HSA-5216234
Reaction Name: PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)
See in Reactome
R-HSA-560510
(
R-HSA-381340
)
R-HSA-5661117
(
R-HSA-3214858
)
R-HSA-5661117
Reaction Name: CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3
See in Reactome
R-HSA-69227
(
R-HSA-69231
)
R-HSA-69227
Reaction Name: Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
See in Reactome
R-HSA-75820
(
R-HSA-75815
)
R-HSA-75820
Reaction Name: Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
See in Reactome
R-HSA-75822
(
R-HSA-75815
)
R-HSA-75822
Reaction Name: Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
See in Reactome
R-HSA-8848414
(
R-HSA-187577;
R-HSA-8849470
)
R-HSA-8848436
(
R-HSA-187577;
R-HSA-8849470
)
R-HSA-8941895
(
R-HSA-69231
)
R-HSA-8941895
Reaction Name: Formation of CDK4/6:CCND complexes
See in Reactome
R-HSA-8941915
(
R-HSA-69231
)
R-HSA-8941915
Reaction Name: Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8942803
(
R-HSA-69231
)
R-HSA-8942803
Reaction Name: Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
See in Reactome
R-HSA-8942836
(
R-HSA-69231
)
R-HSA-8942836
Reaction Name: CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
See in Reactome
R-HSA-9008412
(
R-HSA-8878166
)
R-HSA-9018017
(
R-HSA-69231
)
R-HSA-9018017
Reaction Name: RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9624112
(
R-HSA-9616222
)
R-HSA-9754130
(
R-HSA-69231
)
|
MONDO:0005061 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005061 |
CDK12 |
Q9NYV4 |
2.7.11.22
2.7.11.23
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-212436
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-74160
R-HSA-73857
|
Gene expression (Transcription)
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R-HSA-6797090
(
R-HSA-6796648
)
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
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