DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005044	F12	P00748	3.4.21.38	R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Hemostasis	R-HSA-158300 ( R-HSA-140837 ) R-HSA-158300 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) See in Reactome R-HSA-158313 ( R-HSA-140837 ) R-HSA-158313 Reaction Name: factor XII -> factor XIIa See in Reactome R-HSA-158357 ( R-HSA-140837 ) R-HSA-158357 Reaction Name: factor XIIa binds SERPING1 See in Reactome
MONDO:0005044	CELA2A	P08217	3.4.21.71	R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Developmental Biology	R-HSA-8849857 ( R-HSA-6809371 ) R-HSA-8849857 Reaction Name: KLK5 cleaves and activates CELA2 See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome