DAR - Bologna Biocomputing Group

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0100340	FXN	Q16595	1.16.3.1	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-1362409 R-HSA-1362409 Reactome Name: Mitochondrial iron-sulfur cluster biogenesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome	Metabolism Protein localization	R-HSA-1299475 ( R-HSA-1268020 ) R-HSA-1299475 Reaction Name: TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix See in Reactome R-HSA-1299478 ( R-HSA-1268020 ) R-HSA-1299478 Reaction Name: MPP cleaves targeting peptide (presequence) of matrix precursors See in Reactome R-HSA-1299480 ( R-HSA-1268020 ) R-HSA-1299480 Reaction Name: Precursor proteins enter TIMM23 PAM See in Reactome R-HSA-1362408 ( R-HSA-1362409 ) R-HSA-1362408 Reaction Name: FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster See in Reactome R-HSA-1362416 ( R-HSA-1362409 ) R-HSA-1362416 Reaction Name: Frataxin binds iron See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome

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