DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0060611	MTHFD1	P11586	3.5.4.9 1.5.1.5 6.3.4.3	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200644 ( R-HSA-196757 ) R-HSA-200644 Reaction Name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ See in Reactome R-HSA-200661 ( R-HSA-196757 ) R-HSA-200661 Reaction Name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG See in Reactome R-HSA-200711 ( R-HSA-196757 ) R-HSA-200711 Reaction Name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG See in Reactome R-HSA-200718 ( R-HSA-196757 ) R-HSA-200718 Reaction Name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG See in Reactome R-HSA-200740 ( R-HSA-196757 ) R-HSA-200740 Reaction Name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate See in Reactome