DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0060596)

Number of enzymes:	7
Number of disease:	1
Number of reactomes:	7
Number of reactions:	23

Search results (Disease ID: MONDO:0060596)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0060596	HUWE1	Q7Z6Z7	2.3.2.26	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0060596	RLIM	Q9NVW2	2.3.2.27	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0060596	KDM4B	O94953	1.14.11.66	R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome	R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization DNA Repair Signal Transduction	R-HSA-4724279 ( R-HSA-3214842 ) R-HSA-4724279 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 See in Reactome R-HSA-5661120 ( R-HSA-3214842 ) R-HSA-5661120 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-9011949 ( R-HSA-9018519 ) R-HSA-9011949 Reaction Name: KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers See in Reactome R-HSA-9011952 ( R-HSA-9018519 ) R-HSA-9011952 Reaction Name: ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers See in Reactome R-HSA-9011966 ( R-HSA-9018519 ) R-HSA-9011966 Reaction Name: Estrogen-responsive KDM4B gene expression See in Reactome
MONDO:0060596	TRMT1	Q9NXH9	2.1.1.216	R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6782416 ( R-HSA-6782315 ) R-HSA-6782416 Reaction Name: TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) See in Reactome
MONDO:0060596	TRIP12	Q14669	2.3.2.26	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0060596	DDX6	P26196	3.6.4.13	R-HSA-430039 R-HSA-430039 Reactome Name: mRNA decay by 5' to 3' exoribonuclease See in Reactome	R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Metabolism of RNA	R-HSA-429860 ( R-HSA-430039 ) R-HSA-429860 Reaction Name: DCP1-DCP2 complex decaps mRNA See in Reactome
MONDO:0060596	PUS7	Q96PZ0	5.4.99.-	R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6786583 ( R-HSA-6782315 ) R-HSA-6786583 Reaction Name: PUS7 transforms uridine to pseudouridine in tRNAs See in Reactome