DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0024533)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	1
Number of reactions:	9

Search results (Disease ID: MONDO:0024533)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0024533	ACVRL1	P37023	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8858369 ( R-HSA-201451 ) R-HSA-8858369 Reaction Name: ACVRL1 binds BMP9,BMP10 See in Reactome
MONDO:0024533	BMPR2	Q13873	2.7.11.30	R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome	R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome