DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0019625)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	5
Number of reactions:	26

Search results (Disease ID: MONDO:0019625)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0019625	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0019625	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome