DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0018393)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	2
Number of reactions:	16

Search results (Disease ID: MONDO:0018393)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018393	FANCM	Q8IYD8	3.6.4.13	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785087 ( R-HSA-6783310 ) R-HSA-6785087 Reaction Name: FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA See in Reactome R-HSA-6785126 ( R-HSA-6783310 ) R-HSA-6785126 Reaction Name: FA core complex assembles at DNA interstrand crosslinks (ICLs) See in Reactome R-HSA-6785342 ( R-HSA-6783310 ) R-HSA-6785342 Reaction Name: FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex See in Reactome R-HSA-6785361 ( R-HSA-6783310 ) R-HSA-6785361 Reaction Name: Monoubiquitination of FANCD2:FANCI See in Reactome R-HSA-6785607 ( R-HSA-6783310 ) R-HSA-6785607 Reaction Name: FANCM binds FAAP24 See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome R-HSA-6786155 ( R-HSA-6783310 ) R-HSA-6786155 Reaction Name: POLN binds ICL-DNA See in Reactome R-HSA-6786166 ( R-HSA-6783310 ) R-HSA-6786166 Reaction Name: Translesion synthesis across unhooked ICL by POLN See in Reactome R-HSA-6786171 ( R-HSA-6783310 ) R-HSA-6786171 Reaction Name: FANCD2 deubiquitination by USP1:WDR48 See in Reactome R-HSA-6788385 ( R-HSA-6783310 ) R-HSA-6788385 Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA See in Reactome R-HSA-6788392 ( R-HSA-6783310 ) R-HSA-6788392 Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA See in Reactome
MONDO:0018393	TDRD9	Q8NDG6	3.6.4.13	R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome	Gene expression (Transcription)	R-HSA-5601883 ( R-HSA-5601884 ) R-HSA-5601883 Reaction Name: Complexed PIWIL4 binds cleaved transposon RNA See in Reactome R-HSA-5601897 ( R-HSA-5601884 ) R-HSA-5601897 Reaction Name: MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events See in Reactome R-HSA-5601919 ( R-HSA-5601884 ) R-HSA-5601919 Reaction Name: Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH See in Reactome R-HSA-5629237 ( R-HSA-5601884 ) R-HSA-5629237 Reaction Name: HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH See in Reactome
MONDO:0018393	MEIOB	Q8N635	3.1.-.-