DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0017175)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	8

Search results (Disease ID: MONDO:0017175)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0017175	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome