DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014599	CERT1	Q9Y5P4	-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-429683 ( R-HSA-1660661 ) R-HSA-429683 Reaction Name: CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus See in Reactome R-HSA-429694 ( R-HSA-1660661 ) R-HSA-429694 Reaction Name: CERT1-2 dissociates from the endoplasmic reticulum See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1 See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1,2,3 phosphorylates CERT1-2 See in Reactome R-HSA-429699 ( R-HSA-1660661 ) R-HSA-429699 Reaction Name: CERT1-2 binds ceramide See in Reactome R-HSA-429714 ( R-HSA-1660661 ) R-HSA-429714 Reaction Name: monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP See in Reactome R-HSA-429730 ( R-HSA-1660661 ) R-HSA-429730 Reaction Name: multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate See in Reactome R-HSA-429732 ( R-HSA-1660661 ) R-HSA-429732 Reaction Name: multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B See in Reactome