| Number of enzymes: | 1 |
| Number of disease: | 1 |
| Number of reactomes: | 1 |
| Number of reactions: | 5 |
| DiseaseID | Gene | UniProt | EC numbers | Reactomes | Expanded Reactomes | Reactome roots | Reactions |
|---|---|---|---|---|---|---|---|
| MONDO:0014557 | PNKP | Q96T60 |
3.1.3.32 2.7.1.78 |
R-HSA-5649702
R-HSA-5649702Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwaySee in Reactome |
R-HSA-73894 R-HSA-73884 R-HSA-73933 |
DNA Repair |
R-HSA-5649705
(
R-HSA-5649702
) R-HSA-5649705Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)See in Reactome R-HSA-5649723Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolutionSee in Reactome R-HSA-5649724Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER siteSee in Reactome R-HSA-5649726Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNASee in Reactome |