DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0014256)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	8
Number of reactions:	25

Search results (Disease ID: MONDO:0014256)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014256	NEK2	P51955	2.7.11.1	R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-179409 R-HSA-179409 Reactome Name: APC-Cdc20 mediated degradation of Nek2A See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome	R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome	Organelle biogenesis and maintenance Cell Cycle	R-HSA-179410 ( R-HSA-179409 ) R-HSA-179410 Reaction Name: Association of Nek2A with MCC:APC/C See in Reactome R-HSA-179417 ( R-HSA-179409 ) R-HSA-179417 Reaction Name: Multiubiquitination of Nek2A See in Reactome R-HSA-179421 ( R-HSA-179409 ) R-HSA-179421 Reaction Name: Degradation of multiubiquitinated Nek2A See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome