DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0014058)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	10
Number of reactions:	23

Search results (Disease ID: MONDO:0014058)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014058	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome