DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0013999)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	1
Number of reactions:	10

Search results (Disease ID: MONDO:0013999)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013999	ALPK1	Q96QP1	2.7.11.1	R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome	Immune System	R-HSA-9645394 ( R-HSA-9645460 ) R-HSA-9645394 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645414 ( R-HSA-9645460 ) R-HSA-9645414 Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer See in Reactome R-HSA-9645428 ( R-HSA-9645460 ) R-HSA-9645428 Reaction Name: ALPK1 binds ADP-heptose See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-9645481 ( R-HSA-9645460 ) R-HSA-9645481 Reaction Name: TIFA oligomerization See in Reactome R-HSA-9645501 ( R-HSA-9645460 ) R-HSA-9645501 Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex See in Reactome R-HSA-9645520 ( R-HSA-9645460 ) R-HSA-9645520 Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 See in Reactome R-HSA-9645524 ( R-HSA-9645460 ) R-HSA-9645524 Reaction Name: ALPK1:ADP-heptose binds TIFA See in Reactome R-HSA-9645535 ( R-HSA-9645460 ) R-HSA-9645535 Reaction Name: ALPK1 phosphorylates TIFA See in Reactome