DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013254	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome