DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0011888)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	8
Number of reactions:	45

Search results (Disease ID: MONDO:0011888)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011888	IRAK4	Q9NWZ3	2.7.11.1	R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975110 R-HSA-975110 Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome	R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System Signal Transduction	R-HSA-166082 ( R-HSA-166058 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-446634 ( R-HSA-9020702 ) R-HSA-446634 Reaction Name: IRAK4 is activated by autophosphorylation See in Reactome R-HSA-446648 ( R-HSA-9020702 ) R-HSA-446648 Reaction Name: IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 See in Reactome R-HSA-446684 ( R-HSA-9020702 ) R-HSA-446684 Reaction Name: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation See in Reactome R-HSA-446692 ( R-HSA-9020702 ) R-HSA-446692 Reaction Name: IRAK1 binds to MYD88 within the IL1R complex See in Reactome R-HSA-446694 ( R-HSA-9020702 ) R-HSA-446694 Reaction Name: IRAK4 phosphorylates IRAK1 See in Reactome R-HSA-446701 ( R-HSA-9020702 ) R-HSA-446701 Reaction Name: IRAK4-activated IRAK1 autophosphorylates See in Reactome R-HSA-446862 ( R-HSA-9020702 ) R-HSA-446862 Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6 See in Reactome R-HSA-446868 ( R-HSA-9020702 ) R-HSA-446868 Reaction Name: The Interleukin 1 receptor complex binds Tollip See in Reactome R-HSA-446894 ( R-HSA-9020702 ) R-HSA-446894 Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release See in Reactome R-HSA-450690 ( R-HSA-9020702 ) R-HSA-450690 Reaction Name: hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 See in Reactome R-HSA-450827 ( R-HSA-9020702 ) R-HSA-450827 Reaction Name: hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. See in Reactome R-HSA-8948063 ( R-HSA-9020702 ) R-HSA-8948063 Reaction Name: hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 See in Reactome R-HSA-937022 ( R-HSA-166058 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-975100 ( R-HSA-975138; R-HSA-975155 ) R-HSA-975100 Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex See in Reactome R-HSA-975106 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975106 Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975111 ( R-HSA-975155 ) R-HSA-975111 Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975115 ( R-HSA-975155 ) R-HSA-975115 Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. See in Reactome R-HSA-975118 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975118 Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex See in Reactome R-HSA-975125 ( R-HSA-975155 ) R-HSA-975125 Reaction Name: Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975134 ( R-HSA-975155 ) R-HSA-975134 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 See in Reactome R-HSA-975156 ( R-HSA-975155 ) R-HSA-975156 Reaction Name: IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex See in Reactome R-HSA-975160 ( R-HSA-975155 ) R-HSA-975160 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 See in Reactome R-HSA-975170 ( R-HSA-975155 ) R-HSA-975170 Reaction Name: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 See in Reactome R-HSA-975180 ( R-HSA-975155 ) R-HSA-975180 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 See in Reactome R-HSA-975188 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975188 Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975852 ( R-HSA-975871 ) R-HSA-975852 Reaction Name: IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex See in Reactome R-HSA-975853 ( R-HSA-975871 ) R-HSA-975853 Reaction Name: Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR See in Reactome R-HSA-975857 ( R-HSA-975871 ) R-HSA-975857 Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2 See in Reactome R-HSA-975861 ( R-HSA-975871 ) R-HSA-975861 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex See in Reactome R-HSA-975865 ( R-HSA-975871 ) R-HSA-975865 Reaction Name: IRAK4 autophosphorylation within the complex activated TLR:MyD88 See in Reactome R-HSA-975873 ( R-HSA-975871 ) R-HSA-975873 Reaction Name: IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor See in Reactome R-HSA-975874 ( R-HSA-975871 ) R-HSA-975874 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex See in Reactome R-HSA-975878 ( R-HSA-975871 ) R-HSA-975878 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR See in Reactome R-HSA-975879 ( R-HSA-975871 ) R-HSA-975879 Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex See in Reactome