DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0011860)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	5
Number of reactions:	16

Search results (Disease ID: MONDO:0011860)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011860	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome