DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0008547)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	11
Number of reactions:	32

Search results (Disease ID: MONDO:0008547)

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008547	FGFR3	P22607	2.7.10.1	R-HSA-190372 R-HSA-190372 Reactome Name: FGFR3c ligand binding and activation See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654227 R-HSA-5654227 Reactome Name: Phospholipase C-mediated cascade; FGFR3 See in Reactome R-HSA-190371 R-HSA-190371 Reactome Name: FGFR3b ligand binding and activation See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-190239 R-HSA-190239 Reactome Name: FGFR3 ligand binding and activation See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190261 ( R-HSA-190372 ) R-HSA-190261 Reaction Name: FGFR3c binds to FGF See in Reactome R-HSA-190263 ( R-HSA-190371 ) R-HSA-190263 Reaction Name: FGFR3b binds to FGF See in Reactome R-HSA-190385 ( R-HSA-190371 ) R-HSA-190385 Reaction Name: Autocatalytic phosphorylation of FGFR3b See in Reactome R-HSA-190388 ( R-HSA-190372 ) R-HSA-190388 Reaction Name: Autocatalytic phosphorylation of FGFR3c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654148 ( R-HSA-5654227 ) R-HSA-5654148 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3 See in Reactome R-HSA-5654222 ( R-HSA-5654227 ) R-HSA-5654222 Reaction Name: Activated FGFR3 phosphorylates PLCG1 See in Reactome R-HSA-5654224 ( R-HSA-5654227 ) R-HSA-5654224 Reaction Name: Activated FGFR3 binds PLCG1 See in Reactome R-HSA-5654408 ( R-HSA-5654706 ) R-HSA-5654408 Reaction Name: Activated FGFR3 phosphorylates FRS2 See in Reactome R-HSA-5654409 ( R-HSA-5654706 ) R-HSA-5654409 Reaction Name: Activated FGFR3 binds FRS2 See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654416 ( R-HSA-5654706 ) R-HSA-5654416 Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654623 ( R-HSA-5654706 ) R-HSA-5654623 Reaction Name: Activated FGFR3 binds FRS3 See in Reactome R-HSA-5654625 ( R-HSA-5654704 ) R-HSA-5654625 Reaction Name: Activated FGFR3 binds SHC1 See in Reactome R-HSA-5654628 ( R-HSA-5654706 ) R-HSA-5654628 Reaction Name: Activated FGFR3 phosphorylates FRS3 See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654634 ( R-HSA-5654704 ) R-HSA-5654634 Reaction Name: Activated FGFR3 phosphorylates SHC1 See in Reactome R-HSA-5654637 ( R-HSA-5654710 ) R-HSA-5654637 Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654646 ( R-HSA-5654704 ) R-HSA-5654646 Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome

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