DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0007390)

Number of enzymes:	4
Number of disease:	1
Number of reactomes:	10
Number of reactions:	31

Search results (Disease ID: MONDO:0007390)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007390	CYP2A6	P11509	1.14.14.-	R-HSA-211999 R-HSA-211999 Reactome Name: CYP2E1 reactions See in Reactome R-HSA-211981 R-HSA-211981 Reactome Name: Xenobiotics See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome	Metabolism	R-HSA-143468 ( R-HSA-211981; R-HSA-211999 ) R-HSA-143468 Reaction Name: MEOS oxidizes ethanol to acetaldehyde See in Reactome R-HSA-211881 ( R-HSA-211981 ) R-HSA-211881 Reaction Name: Coumarin is 7-hydroxylated by CYP2A13 See in Reactome R-HSA-212005 ( R-HSA-211981 ) R-HSA-212005 Reaction Name: CYP2F1 dehydrogenates 3-methylindole See in Reactome R-HSA-76354 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76354 Reaction Name: Vinyl chloride is oxidized to 2-Chloroethylene oxide See in Reactome R-HSA-76397 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76397 Reaction Name: Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) See in Reactome R-HSA-76416 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76416 Reaction Name: Benzene is hydroxylated to phenol See in Reactome R-HSA-76434 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76434 Reaction Name: Dehalogenation of carbon tetrachloride to form a free radical See in Reactome R-HSA-76453 ( R-HSA-211981 ) R-HSA-76453 Reaction Name: Coumarin is 7-hydroxylated by CYP2A6 See in Reactome R-HSA-76475 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76475 Reaction Name: Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide See in Reactome
MONDO:0007390	CYP2C9	P11712	1.14.14.52 1.14.14.53 1.14.14.51 1.14.14.1	R-HSA-211999 R-HSA-211999 Reactome Name: CYP2E1 reactions See in Reactome R-HSA-211981 R-HSA-211981 Reactome Name: Xenobiotics See in Reactome R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome R-HSA-9027307 R-HSA-9027307 Reactome Name: Biosynthesis of maresin-like SPMs See in Reactome R-HSA-2142670 R-HSA-2142670 Reactome Name: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018682 R-HSA-9018682 Reactome Name: Biosynthesis of maresins See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-143468 ( R-HSA-211981; R-HSA-211999 ) R-HSA-143468 Reaction Name: MEOS oxidizes ethanol to acetaldehyde See in Reactome R-HSA-211881 ( R-HSA-211981 ) R-HSA-211881 Reaction Name: Coumarin is 7-hydroxylated by CYP2A13 See in Reactome R-HSA-211910 ( R-HSA-211981 ) R-HSA-211910 Reaction Name: CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation See in Reactome R-HSA-211929 ( R-HSA-211981 ) R-HSA-211929 Reaction Name: CYP2C19 5-hydroxylates omeprazole See in Reactome R-HSA-211966 ( R-HSA-211981 ) R-HSA-211966 Reaction Name: CYP2D6 4-hydroxylates debrisoquine See in Reactome R-HSA-211988 ( R-HSA-211981 ) R-HSA-211988 Reaction Name: CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation See in Reactome R-HSA-211991 ( R-HSA-211981 ) R-HSA-211991 Reaction Name: Cyclophosphamide is 4-hydroxylated by CYP2B6 See in Reactome R-HSA-212004 ( R-HSA-211981 ) R-HSA-212004 Reaction Name: CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation See in Reactome R-HSA-212005 ( R-HSA-211981 ) R-HSA-212005 Reaction Name: CYP2F1 dehydrogenates 3-methylindole See in Reactome R-HSA-2161814 ( R-HSA-2142816 ) R-HSA-2161814 Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2) See in Reactome R-HSA-2161899 ( R-HSA-2142670 ) R-HSA-2161899 Reaction Name: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) See in Reactome R-HSA-76354 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76354 Reaction Name: Vinyl chloride is oxidized to 2-Chloroethylene oxide See in Reactome R-HSA-76397 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76397 Reaction Name: Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) See in Reactome R-HSA-76416 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76416 Reaction Name: Benzene is hydroxylated to phenol See in Reactome R-HSA-76434 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76434 Reaction Name: Dehalogenation of carbon tetrachloride to form a free radical See in Reactome R-HSA-76456 ( R-HSA-211981 ) R-HSA-76456 Reaction Name: O-atom dealkylation of dextromethorphan See in Reactome R-HSA-76475 ( R-HSA-211981; R-HSA-211999 ) R-HSA-76475 Reaction Name: Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide See in Reactome R-HSA-9027043 ( R-HSA-9027307 ) R-HSA-9027043 Reaction Name: CYPs hydroxylate DHA to 14(R)-HDHA See in Reactome
MONDO:0007390	VKORC1	Q9BQB6	1.17.4.4	R-HSA-6806664 R-HSA-6806664 Reactome Name: Metabolism of vitamin K See in Reactome	R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-159790 ( R-HSA-6806664 ) R-HSA-159790 Reaction Name: VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) See in Reactome R-HSA-9026967 ( R-HSA-6806664 ) R-HSA-9026967 Reaction Name: VKORC1 inhibitors binds VKORC1 dimer See in Reactome
MONDO:0007390	CYP4F2	P78329	1.14.14.94 1.14.14.78 1.14.14.1 1.14.14.79	R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-211935 R-HSA-211935 Reactome Name: Fatty acids See in Reactome R-HSA-211958 R-HSA-211958 Reactome Name: Miscellaneous substrates See in Reactome R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211873 ( R-HSA-211979; R-HSA-2142691 ) R-HSA-211873 Reaction Name: CYP4F2, 4F3 20-hydroxylate LTB4 See in Reactome R-HSA-211904 ( R-HSA-211935 ) R-HSA-211904 Reaction Name: CYP4F12 18-hydroxylates ARA See in Reactome R-HSA-211919 ( R-HSA-211979 ) R-HSA-211919 Reaction Name: CYP4F8 19-hydroxylates PGH2 See in Reactome R-HSA-211924 ( R-HSA-211935 ) R-HSA-211924 Reaction Name: CYP4B1 12-hydroxylates ARA See in Reactome R-HSA-211962 ( R-HSA-211958 ) R-HSA-211962 Reaction Name: CYP4F11 16-hydroxylates 3OH-PALM See in Reactome R-HSA-215526 ( R-HSA-211979 ) R-HSA-215526 Reaction Name: CYP4F3 20-hydroxylates LTB4 See in Reactome R-HSA-2161745 ( R-HSA-2142691 ) R-HSA-2161745 Reaction Name: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-2161792 ( R-HSA-2142691 ) R-HSA-2161792 Reaction Name: 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome R-HSA-76466 ( R-HSA-211935 ) R-HSA-76466 Reaction Name: CYP4A11 12-hydroxylates DDCX See in Reactome