DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0005835)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	4
Number of reactions:	12

Search results (Disease ID: MONDO:0005835)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005835	FAN1	Q9Y2M0	3.1.4.1 3.1.21.-	R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome	DNA Repair	R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0005835	PMS2	P54278	3.1.-.-	R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-5358510 ( R-HSA-5358565 ) R-HSA-5358510 Reaction Name: MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA See in Reactome R-HSA-5358512 ( R-HSA-5358606 ) R-HSA-5358512 Reaction Name: MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more See in Reactome R-HSA-5358518 ( R-HSA-5358565 ) R-HSA-5358518 Reaction Name: MLH1:PMS2 makes single strand incision near 1-2 base mismatch See in Reactome R-HSA-5358519 ( R-HSA-5358606 ) R-HSA-5358519 Reaction Name: MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA See in Reactome R-HSA-5358545 ( R-HSA-5358606 ) R-HSA-5358545 Reaction Name: EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) See in Reactome R-HSA-5358597 ( R-HSA-5358565 ) R-HSA-5358597 Reaction Name: EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) See in Reactome R-HSA-5358599 ( R-HSA-5358565 ) R-HSA-5358599 Reaction Name: EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch See in Reactome R-HSA-5358619 ( R-HSA-5358606 ) R-HSA-5358619 Reaction Name: EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) See in Reactome R-HSA-5444523 ( R-HSA-5358565 ) R-HSA-5444523 Reaction Name: Formation of MSH1:PMS2 Complex See in Reactome R-HSA-6806405 ( R-HSA-6796648 ) R-HSA-6806405 Reaction Name: TP53 stimulates PMS2 expression See in Reactome