DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0005138)

Number of enzymes:	3
Number of disease:	1
Number of reactomes:	35
Number of reactions:	91

Search results (Disease ID: MONDO:0005138)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005138	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0005138	MET	P08581	2.7.10.1	R-HSA-6806942 R-HSA-6806942 Reactome Name: MET Receptor Activation See in Reactome R-HSA-9022699 R-HSA-9022699 Reactome Name: MECP2 regulates neuronal receptors and channels See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-8875513 R-HSA-8875513 Reactome Name: MET interacts with TNS proteins See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-8875791 R-HSA-8875791 Reactome Name: MET activates STAT3 See in Reactome R-HSA-8875656 R-HSA-8875656 Reactome Name: MET receptor recycling See in Reactome R-HSA-8874081 R-HSA-8874081 Reactome Name: MET activates PTK2 signaling See in Reactome R-HSA-9734091 R-HSA-9734091 Reactome Name: Drug-mediated inhibition of MET activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Signal Transduction Developmental Biology	R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-400677 ( R-HSA-416550 ) R-HSA-400677 Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-416546 ( R-HSA-416550 ) R-HSA-416546 Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416562 ( R-HSA-416550 ) R-HSA-416562 Reaction Name: p190RhoGAP binds Plexin-B1 See in Reactome R-HSA-419646 ( R-HSA-416550 ) R-HSA-419646 Reaction Name: SEMA4D interacts with Plexin-B1:Met See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6800298 ( R-HSA-6806942 ) R-HSA-6800298 Reaction Name: HGF dimer binds MET See in Reactome R-HSA-6806957 ( R-HSA-6806942 ) R-HSA-6806957 Reaction Name: MET receptor dimerizes See in Reactome R-HSA-6806974 ( R-HSA-6806942 ) R-HSA-6806974 Reaction Name: MET dimers autophosphorylate See in Reactome R-HSA-6807008 ( R-HSA-6807004 ) R-HSA-6807008 Reaction Name: PTPRJ dephosphorylates MET See in Reactome R-HSA-6807027 ( R-HSA-6807004 ) R-HSA-6807027 Reaction Name: PTPN1 and PTPN2 dephosphorylate MET See in Reactome R-HSA-8851804 ( R-HSA-8851805 ) R-HSA-8851804 Reaction Name: Activated MET recruits GRB2-1:SOS1 See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851842 ( R-HSA-8851805 ) R-HSA-8851842 Reaction Name: MUC20 binds MET and inhibits GRB2 binding See in Reactome R-HSA-8851859 ( R-HSA-8851805 ) R-HSA-8851859 Reaction Name: Activated MET binds RANBP9 and SOS1 See in Reactome R-HSA-8851866 ( R-HSA-8851805 ) R-HSA-8851866 Reaction Name: MET binds RANBP10 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851888 ( R-HSA-8851805 ) R-HSA-8851888 Reaction Name: MET binds SHC1-2 See in Reactome R-HSA-8851890 ( R-HSA-8851805 ) R-HSA-8851890 Reaction Name: MET phosphorylates SHC1-2 See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8851900 ( R-HSA-8851805 ) R-HSA-8851900 Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1 See in Reactome R-HSA-8851908 ( R-HSA-8851907 ) R-HSA-8851908 Reaction Name: Activated MET binds GAB1 See in Reactome R-HSA-8851919 ( R-HSA-8851907 ) R-HSA-8851919 Reaction Name: Activated MET binds GAB1 and GRB2 See in Reactome R-HSA-8851933 ( R-HSA-8851907 ) R-HSA-8851933 Reaction Name: MET phosphorylates GAB1 See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8874078 ( R-HSA-8874081 ) R-HSA-8874078 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-8874079 ( R-HSA-8874081 ) R-HSA-8874079 Reaction Name: PTK2 binds activated MET See in Reactome R-HSA-8874080 ( R-HSA-8874081 ) R-HSA-8874080 Reaction Name: SRC phosphorylates PTK2 See in Reactome R-HSA-8874082 ( R-HSA-8874081 ) R-HSA-8874082 Reaction Name: MET phosphorylates PTK2 See in Reactome R-HSA-8874083 ( R-HSA-8874081 ) R-HSA-8874083 Reaction Name: p-Y397-PTK2 binds SRC See in Reactome R-HSA-8874685 ( R-HSA-6807004 ) R-HSA-8874685 Reaction Name: CBL binds MET See in Reactome R-HSA-8875183 ( R-HSA-6807004 ) R-HSA-8875183 Reaction Name: CBL monoubiquitinates activated MET See in Reactome R-HSA-8875374 ( R-HSA-6807004 ) R-HSA-8875374 Reaction Name: MET binds LRIG1 See in Reactome R-HSA-8875431 ( R-HSA-6807004 ) R-HSA-8875431 Reaction Name: LRIG1 undergoes ubiquitination See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome R-HSA-8875451 ( R-HSA-6807004 ) R-HSA-8875451 Reaction Name: MET phosphorylates CBL See in Reactome R-HSA-8875482 ( R-HSA-6807004 ) R-HSA-8875482 Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET See in Reactome R-HSA-8875490 ( R-HSA-6807004 ) R-HSA-8875490 Reaction Name: EPS15 and HGS bind ubiquitinated MET See in Reactome R-HSA-8875523 ( R-HSA-8875513 ) R-HSA-8875523 Reaction Name: MET binds TNS3 See in Reactome R-HSA-8875531 ( R-HSA-8875513 ) R-HSA-8875531 Reaction Name: MET binds TNS4 See in Reactome R-HSA-8875540 ( R-HSA-8875555 ) R-HSA-8875540 Reaction Name: GAB1 recruits CRK,CRKL to MET See in Reactome R-HSA-8875558 ( R-HSA-8875555 ) R-HSA-8875558 Reaction Name: RAPGEF1 binds CRK,CRKL See in Reactome R-HSA-8875568 ( R-HSA-8875555 ) R-HSA-8875568 Reaction Name: RAPGEF1 activates RAP1 See in Reactome R-HSA-8875576 ( R-HSA-8875555 ) R-HSA-8875576 Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8875659 ( R-HSA-8875656 ) R-HSA-8875659 Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane See in Reactome R-HSA-8875661 ( R-HSA-8875656 ) R-HSA-8875661 Reaction Name: GGA3 associates with activated MET receptor See in Reactome R-HSA-8875816 ( R-HSA-8875791 ) R-HSA-8875816 Reaction Name: STAT3 binds activated MET receptor See in Reactome R-HSA-8875817 ( R-HSA-8875791 ) R-HSA-8875817 Reaction Name: MET phosphorylates STAT3 See in Reactome R-HSA-8986940 ( R-HSA-9022699 ) R-HSA-8986940 Reaction Name: MET gene transcription is stimulated by MECP2 See in Reactome R-HSA-9734070 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9734070 Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET See in Reactome R-HSA-9735946 ( R-HSA-6807004; R-HSA-9734091 ) R-HSA-9735946 Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET See in Reactome
MONDO:0005138	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome