DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0005105)

Number of enzymes:	2
Number of disease:	1
Number of reactomes:	19
Number of reactions:	95

Search results (Disease ID: MONDO:0005105)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005105	PDGFRA	P16234	2.7.10.1	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-1524182 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524182 Reaction Name: Activated PLC gamma dissociates from the PDGF receptor See in Reactome R-HSA-1524186 ( R-HSA-186763; R-HSA-186797 ) R-HSA-1524186 Reaction Name: Phosphorylation of PLCgamma by PDGFR See in Reactome R-HSA-186765 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186765 Reaction Name: PLC-gamma binds to the active receptor See in Reactome R-HSA-186773 ( R-HSA-186797 ) R-HSA-186773 Reaction Name: PDGF dimer binds two receptors simultaneously See in Reactome R-HSA-186778 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-186780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-186819 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186819 Reaction Name: SH2 domain of Src binds to the active receptor See in Reactome R-HSA-186826 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186826 Reaction Name: GRB2:SOS1 complex binds to the active receptor See in Reactome R-HSA-186834 ( R-HSA-186763; R-HSA-186797 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-380780 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380780 Reaction Name: Activation of Src See in Reactome R-HSA-380782 ( R-HSA-186763; R-HSA-186797 ) R-HSA-380782 Reaction Name: STAT binds to the active receptor See in Reactome R-HSA-382052 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382052 Reaction Name: p130Cas and C3G bind PDGFR bound Crk See in Reactome R-HSA-382055 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382055 Reaction Name: Grb7 binds to the active PDGF receptor See in Reactome R-HSA-382056 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382056 Reaction Name: Crk binds to the active PDGF receptor See in Reactome R-HSA-382058 ( R-HSA-186763; R-HSA-186797 ) R-HSA-382058 Reaction Name: Nck binds to the active PDGF receptor See in Reactome R-HSA-389083 ( R-HSA-186797 ) R-HSA-389083 Reaction Name: Autophosphorylation of PDGF alpha receptors See in Reactome R-HSA-389086 ( R-HSA-186797 ) R-HSA-389086 Reaction Name: Autophosphorylation of PDGF alpha/beta receptors See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864036 ( R-HSA-186797 ) R-HSA-8864036 Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021 See in Reactome R-HSA-9674015 ( R-HSA-186797 ) R-HSA-9674015 Reaction Name: Olaratumab binds PDGFRA See in Reactome R-HSA-9674093 ( R-HSA-186797 ) R-HSA-9674093 Reaction Name: PDGFRs bind type I TKI See in Reactome R-HSA-9674095 ( R-HSA-186797 ) R-HSA-9674095 Reaction Name: PDGFRs bind type II TKI See in Reactome
MONDO:0005105	ERBB4	Q15303	2.7.10.1	R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Neuronal System Signal Transduction	R-HSA-1236398 ( R-HSA-1236394 ) R-HSA-1236398 Reaction Name: ERBB4 binds NRGs or EGF-like ligands See in Reactome R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250220 ( R-HSA-1236394 ) R-HSA-1250220 Reaction Name: Homodimerization of ERBB4 See in Reactome R-HSA-1250315 ( R-HSA-1236394 ) R-HSA-1250315 Reaction Name: Trans-autophosphorylation of ERBB4 homodimers See in Reactome R-HSA-1250346 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250348 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250348 Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers See in Reactome R-HSA-1250353 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250357 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250357 Reaction Name: SHC1 binds P-ERBB4 isoform dimers See in Reactome R-HSA-1250370 ( R-HSA-1236394; R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250380 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250380 Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1251992 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1251992 Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17 See in Reactome R-HSA-1251997 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-1252013 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1252013 Reaction Name: Translocation of ERBB4s80 to the nucleus See in Reactome R-HSA-1253282 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1253282 Reaction Name: ERBB4 ubiquitination by WWP1/ITCH See in Reactome R-HSA-1253300 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1253300 Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases See in Reactome R-HSA-1253319 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253319 Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus See in Reactome R-HSA-1253321 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253321 Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 See in Reactome R-HSA-1253325 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253325 Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex See in Reactome R-HSA-1253343 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1253343 Reaction Name: WWOX binds ERBB4s80 See in Reactome R-HSA-1254248 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254248 Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus See in Reactome R-HSA-1254251 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254251 Reaction Name: ERBB4s80 binds YAP1 See in Reactome R-HSA-1254285 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254285 Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus See in Reactome R-HSA-1254290 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254290 Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A See in Reactome R-HSA-1254291 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254291 Reaction Name: ERBB4s80 binds STAT5A See in Reactome R-HSA-1254376 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-1254376 Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix See in Reactome R-HSA-1254386 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-1254386 Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1 See in Reactome R-HSA-1254392 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-1254392 Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen See in Reactome R-HSA-1306969 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306969 Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1306979 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1973956 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1973956 Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer See in Reactome R-HSA-1977296 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-1977296 Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer See in Reactome R-HSA-1977958 ( R-HSA-1236394 ) R-HSA-1977958 Reaction Name: ERBB4 forms heterodimers with ERBB3 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8954179 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954179 Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 See in Reactome R-HSA-8954182 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954182 Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter See in Reactome R-HSA-8954185 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954185 Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter See in Reactome R-HSA-8954199 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954199 Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen See in Reactome R-HSA-8954207 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954207 Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter See in Reactome R-HSA-8954208 ( R-HSA-1236394; R-HSA-1251985; R-HSA-9018519 ) R-HSA-8954208 Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter See in Reactome R-HSA-8954224 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-8954224 Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9612219 ( R-HSA-1236394; R-HSA-1253288 ) R-HSA-9612219 Reaction Name: ERBB4s80 binds to SRC See in Reactome R-HSA-9612243 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612243 Reaction Name: APOE gene transcription is stimulated by ERBB4s80 See in Reactome R-HSA-9612246 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612246 Reaction Name: ERBB4s80 binds the APOE gene See in Reactome R-HSA-9612255 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612255 Reaction Name: ERBB4s80 binds ADAP1 gene See in Reactome R-HSA-9612257 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612257 Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80 See in Reactome R-HSA-9612277 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612277 Reaction Name: SPARC gene transcription is stimulated by ERBB4s80 See in Reactome R-HSA-9612278 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612278 Reaction Name: ERBB4s80 binds SPARC gene See in Reactome R-HSA-9612440 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612440 Reaction Name: ERBB4s80 binds the MXD4 gene See in Reactome R-HSA-9612444 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612444 Reaction Name: ERBB4s80 binds STMN1 gene See in Reactome R-HSA-9612445 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612445 Reaction Name: STMN1 gene expression is stimulated by ERBB4s80 See in Reactome R-HSA-9612448 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612448 Reaction Name: MXD4 gene expression is stimulated by ERBB4s80 See in Reactome R-HSA-9612593 ( R-HSA-1236394 ) R-HSA-9612593 Reaction Name: ERBB4 binds DLG4 See in Reactome R-HSA-9612639 ( R-HSA-1236394 ) R-HSA-9612639 Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1 See in Reactome R-HSA-9612671 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612671 Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1 See in Reactome R-HSA-9612672 ( R-HSA-1236394; R-HSA-1251985 ) R-HSA-9612672 Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter See in Reactome