DAR - Bologna Biocomputing Group

Search summary (Disease ID: MONDO:0000437)

Number of enzymes:	4
Number of disease:	1
Number of reactomes:	10
Number of reactions:	13

Search results (Disease ID: MONDO:0000437)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000437	PLA2G6	O60733	3.1.1.4 3.1.1.5 3.1.2.2	R-HSA-1482798 R-HSA-1482798 Reactome Name: Acyl chain remodeling of CL See in Reactome R-HSA-1482839 R-HSA-1482839 Reactome Name: Acyl chain remodelling of PE See in Reactome R-HSA-6811436 R-HSA-6811436 Reactome Name: COPI-independent Golgi-to-ER retrograde traffic See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1482788 R-HSA-1482788 Reactome Name: Acyl chain remodelling of PC See in Reactome	R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-8856688 R-HSA-8856688 Reactome Name: Golgi-to-ER retrograde transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-6811442 R-HSA-6811442 Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1482778 ( R-HSA-1482798 ) R-HSA-1482778 Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM) See in Reactome R-HSA-1482856 ( R-HSA-1482788 ) R-HSA-1482856 Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5] See in Reactome R-HSA-1482884 ( R-HSA-1482839 ) R-HSA-1482884 Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2] See in Reactome R-HSA-2029475 ( R-HSA-2029485 ) R-HSA-2029475 Reaction Name: Production of AA by iPLA2 upon FCGR activation See in Reactome R-HSA-8848484 ( R-HSA-6811436 ) R-HSA-8848484 Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane See in Reactome
MONDO:0000437	MFN2	O95140	3.6.5.-	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9013419 R-HSA-9013419 Reactome Name: RHOT2 GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9715370 R-HSA-9715370 Reactome Name: Miro GTPase Cycle See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Signal Transduction Hemostasis	R-HSA-5205649 ( R-HSA-5205685 ) R-HSA-5205649 Reaction Name: p62 links damaged mitochondria to LC3 See in Reactome R-HSA-5205663 ( R-HSA-5205685 ) R-HSA-5205663 Reaction Name: LC3 binds the autophagosome membrane Atg5-Atg12 complex See in Reactome R-HSA-5205673 ( R-HSA-5205685 ) R-HSA-5205673 Reaction Name: p62 binds ubiquitinated mitochondrial substrates See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-9018824 ( R-HSA-9013419 ) R-HSA-9018824 Reaction Name: RHOT2 binds effectors at the mitochondrial outer membrane See in Reactome R-HSA-992703 ( R-HSA-983231 ) R-HSA-992703 Reaction Name: Mitofusins trans-interact linking mitochondria prior to fusion See in Reactome
MONDO:0000437	PTRH2	Q9Y3E5	3.1.1.29	R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-5696872 ( R-HSA-5689880 ) R-HSA-5696872 Reaction Name: USP30 deubiquitinates Ub-MOM proteins See in Reactome
MONDO:0000437	PMM2	O15305	5.4.2.8	R-HSA-446205 R-HSA-446205 Reactome Name: Synthesis of GDP-mannose See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-446201 ( R-HSA-446205 ) R-HSA-446201 Reaction Name: PMM1,2 isomerise Man6P to Man1P See in Reactome